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Literature summary for 3.3.2.10 extracted from

  • Cronin, A.; Decker, M.; Arand, M.
    Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase (2011), J. Lipid Res., 52, 712-719.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0046
-
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid pH 7.4, 37°C Rattus norvegicus
0.0073
-
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid pH 7.4, 37°C Homo sapiens
0.0108
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid pH 7.4, 37°C Homo sapiens
0.0147
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid pH 7.4, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O Mus musculus i.e. hepoxilin B3 (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O Mus musculus i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O i.e. hepoxilin B3 Mus musculus (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
?
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O i.e. hepoxilin B3 Homo sapiens (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
?
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O i.e. hepoxilin B3 Rattus norvegicus (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase Mus musculus (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase Homo sapiens (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase Rattus norvegicus (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
?

Synonyms

Synonyms Comment Organism
hepoxilin hydrolase
-
Mus musculus
hepoxilin hydrolase
-
Homo sapiens
hepoxilin hydrolase
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid pH 7.4, 37°C Homo sapiens
0.42
-
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid pH 7.4, 37°C Homo sapiens
0.6
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid pH 7.4, 37°C Rattus norvegicus
1.88
-
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid pH 7.4, 37°C Rattus norvegicus

General Information

General Information Comment Organism
physiological function hepoxilin hydrolase activity is abolished in liver preparations from sEH-/- mice, and liver homogenates of sEH-/- mice show elevated basal levels of hepoxilins but lowered levels of trioxilins compared with wild-type animals Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
12
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid pH 7.4, 37°C Homo sapiens
51
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid pH 7.4, 37°C Rattus norvegicus
58
-
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid pH 7.4, 37°C Homo sapiens
450
-
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid pH 7.4, 37°C Rattus norvegicus