Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
expression in Escherichia coli | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0046 | - |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Rattus norvegicus | |
0.0073 | - |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Homo sapiens | |
0.0108 | - |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Homo sapiens | |
0.0147 | - |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O | Mus musculus | i.e. hepoxilin B3 | (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid | - |
? | |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O | Mus musculus | i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase | (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O | i.e. hepoxilin B3 | Mus musculus | (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid | - |
? | |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O | i.e. hepoxilin B3 | Homo sapiens | (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid | - |
? | |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O | i.e. hepoxilin B3 | Rattus norvegicus | (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid | - |
? | |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O | i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase | Mus musculus | (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid | - |
? | |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O | i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase | Homo sapiens | (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid | - |
? | |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O | i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase | Rattus norvegicus | (8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hepoxilin hydrolase | - |
Mus musculus |
hepoxilin hydrolase | - |
Homo sapiens |
hepoxilin hydrolase | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Homo sapiens | |
0.42 | - |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Homo sapiens | |
0.6 | - |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Rattus norvegicus | |
1.88 | - |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | hepoxilin hydrolase activity is abolished in liver preparations from sEH-/- mice, and liver homogenates of sEH-/- mice show elevated basal levels of hepoxilins but lowered levels of trioxilins compared with wild-type animals | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
12 | - |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Homo sapiens | |
51 | - |
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Rattus norvegicus | |
58 | - |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Homo sapiens | |
450 | - |
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid | pH 7.4, 37°C | Rattus norvegicus |