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Literature summary for 3.3.2.10 extracted from
- Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation (2010), J. Mol. Cell. Cardiol., 48, 331-341.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mice lacking sEH have significantly higher circulating EET levels and lower blood pressure compared to wild-type mice, administration of an sEH inhibitor significantly lowers blood pressure in various rodent models of hypertension, and Ephx2 is a susceptibility gene for hypertension-associated heart failure, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | administration of an sEH inhibitor significantly attenuates LPS-mediated induction of hepatic COX-2 expression and circulating PGE2 levels in mice | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Mus musculus | - |
- |
| soluble | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? |  |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 11,12-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 5,6-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 8,9-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
8,9-dihydroxyeicosatrienoic acid | - |
? | |
| additional information | Mus musculus | sEH rapidly hydrolyzes eicosatrienoic acids to their corresponding dihydroxyeicosatrienoic acid, DHET, metabolites, which, in general, are much less biologically active than eicosatrienoic acids. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation, overview. functional impact of CYP epoxygenase-derived eicosatrienoic acids biosynthesis and sEH-mediated xyeicosatrienoic acids hydrolysis on key inflammatory process in the cardiovascular system | ? | - |
? | |
| additional information | Homo sapiens | sEH rapidly hydrolyzes eicosatrienoic acids to their corresponding dihydroxyeicosatrienoic acid, DHET, metabolites, which, in general, are much less biologically active than eicosatrienoic acids. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation, overview. functional impact of CYP epoxygenase-derived eicosatrienoic acids biosynthesis and sEH-mediated xyeicosatrienoic acids hydrolysis on key inflammatory process in the cardiovascular system | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P34913 | gene EPHX2 | - |
| Mus musculus | P34914 | gene EPHX2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | - |
Mus musculus | - |
| cardiomyocyte | - |
Mus musculus | - |
| cardiomyocyte | - |
Homo sapiens | - |
| endothelial cell | - |
Mus musculus | - |
| endothelial cell | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| additional information | sEH is expressed and metabolically active in various tissues and cell types, including endothelial cells and cardiomyocytes | Mus musculus | - |
| additional information | sEH is expressed and metabolically active in various tissues and cell types, including endothelial cells and cardiomyocytes | Homo sapiens | - |
| myocardium | - |
Mus musculus | - |
| myocardium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 8,9-dihydroxyeicosatrienoic acid | - |
? | |
| additional information | sEH rapidly hydrolyzes eicosatrienoic acids to their corresponding dihydroxyeicosatrienoic acid, DHET, metabolites, which, in general, are much less biologically active than eicosatrienoic acids. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation, overview. functional impact of CYP epoxygenase-derived eicosatrienoic acids biosynthesis and sEH-mediated xyeicosatrienoic acids hydrolysis on key inflammatory process in the cardiovascular system | Mus musculus | ? | - |
? | |
| additional information | sEH rapidly hydrolyzes eicosatrienoic acids to their corresponding dihydroxyeicosatrienoic acid, DHET, metabolites, which, in general, are much less biologically active than eicosatrienoic acids. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation, overview. functional impact of CYP epoxygenase-derived eicosatrienoic acids biosynthesis and sEH-mediated xyeicosatrienoic acids hydrolysis on key inflammatory process in the cardiovascular system | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EPHX2 | - |
Mus musculus |
| EPHX2 | - |
Homo sapiens |
| SEH | - |
Mus musculus |
| SEH | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | administration of an sEH inhibitor significantly attenuates LPS-mediated induction of hepatic COX-2 expression and circulating PGE2 levels in mice. Inhibition of sEH-mediated EET hydrolysis has also significantly reduced cerebral infarct volume in rodents after middle cerebral artery occlusion. sEHI treatment downregulates proinflammatory gene expression in the aorta and circulating levels in serum, and reduces inflammatory cell infiltration into the vascular wall | Mus musculus |
| metabolism | overview of CYP epoxygenase pathway metabolism involving sEH | Mus musculus |
| metabolism | overview of CYP epoxygenase pathway metabolism involving sEH | Homo sapiens |
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Release 2023.1 (January 2023)
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