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Literature summary for 3.3.2.10 extracted from

  • Tsai, H.J.; Hwang, S.H.; Morisseau, C.; Yang, J.; Jones, P.D.; Kasagami, T.; Kim, I.H.; Hammock, B.D.
    Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs (2010), Eur. J. Pharm. Sci., 40, 222-238.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
-
 Canis lupus familiaris
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
-
 Homo sapiens
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Canis lupus familiaris
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Homo sapiens
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
-
 Canis lupus familiaris
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
-
 Homo sapiens
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
-
 Canis lupus familiaris
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
-
 Homo sapiens
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
 Canis lupus familiaris
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
 Homo sapiens
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Canis lupus familiaris
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Homo sapiens
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
-
 Canis lupus familiaris
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
-
 Homo sapiens
2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
-
 Canis lupus familiaris
2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
-
 Homo sapiens
3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
 Canis lupus familiaris
3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
 Homo sapiens
4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
 Canis lupus familiaris
4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
 Homo sapiens
4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
 Canis lupus familiaris
4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
 Homo sapiens
methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
-
 Canis lupus familiaris
methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
-
 Homo sapiens
N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
 Canis lupus familiaris
N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
 Homo sapiens
N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
 Canis lupus familiaris
N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
 Homo sapiens
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid i.e. t-AUCB Canis lupus familiaris
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid i.e. t-AUCB Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Canis lupus familiaris 5829
-
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Canis lupus familiaris
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens P34913
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Canis lupus familiaris (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate + H2O i.e. CMNPC, a fluorescent substrate Canis lupus familiaris ?
-
 ?
cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate + H2O i.e. CMNPC, a fluorescent substrate Homo sapiens ?
-
 ?
rac trans-1,3-diphenylpropene oxide + H2O
-
 Canis lupus familiaris ?
-
 ?
rac trans-1,3-diphenylpropene oxide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Canis lupus familiaris
SEH
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Canis lupus familiaris
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Canis lupus familiaris
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
-
 Homo sapiens 4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
0.000001
-
-
 Homo sapiens 3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
0.000002
-
-
 Homo sapiens 4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
0.000003
-
-
 Homo sapiens 12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
0.000003
-
-
 Homo sapiens methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
0.000003
-
-
 Homo sapiens 1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
0.000012
-
-
 Homo sapiens 1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
0.000013
-
-
 Homo sapiens 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
0.000014
-
-
 Homo sapiens 1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.000015
-
-
 Homo sapiens 1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.000028
-
-
 Homo sapiens 1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
0.0000283
-
-
 Homo sapiens 2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
0.0000399
-
-
 Homo sapiens N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
0.000274
-
-
 Homo sapiens N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide