Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.3.2.10 extracted from

  • Eldrup, A.B.; Soleymanzadeh, F.; Farrow, N.A.; Kukulka, A.; De Lombaert, S.
    Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase (2010), Bioorg. Med. Chem. Lett., 20, 571-575.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
-
 Rattus norvegicus
1-cyclohexyl-3-dodecylurea i.e. CDU Rattus norvegicus
1-[(2,4-dichlorobenzyl)carbamoyl]piperidine-4-carboxylic acid
-
 Rattus norvegicus
1-[[4-(trifluoromethoxy)phenyl]carbamoyl]piperidine-4-carboxylic acid
-
 Rattus norvegicus
12-(3-adamantan-1-yl-ureido)dodecanoic acid i.e. AUDA Rattus norvegicus
2-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
2-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
3-(hydroxymethyl)-N-(1-phenylethyl)piperidine-1-carboxamide
-
 Rattus norvegicus
3-(hydroxymethyl)-N-(2-methylbenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
3-(hydroxymethyl)-N-(3-methylbenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
3-(hydroxymethyl)-N-(4-methylbenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
3-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
3-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]-piperidinecarboxamide
-
 Rattus norvegicus
4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
4-(2-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
4-(4-chlorophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
4-(4-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
 Rattus norvegicus
4-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
4-([1-[(2,4-dichlorobenzyl)carbamoyl]piperidin-4-yl]oxy)benzoic acid
-
 Rattus norvegicus
4-benzyl-N-(2,4-dichlorobenzyl)-4-hydroxypiperidine-1-carboxamide
-
 Rattus norvegicus
4-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
additional information inhibitor screening, design, and synthesis, overview. Inhibition of sEH leads to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects Rattus norvegicus
N-(2,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-(pyridin-2-ylmethyl)piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-hydroxy-4-phenylpiperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-phenoxypiperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[(4-fluorophenyl)sulfonyl]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[2-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[3-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[4-(methylcarbamoyl)phenoxy]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[4-(methylsulfamoyl)phenoxy]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[4-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-4-[[(4-fluorophenyl)sulfonyl]amino]piperidine-1-carboxamide
-
 Rattus norvegicus
N-(3,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
-
 Rattus norvegicus
N-benzyl-3-(hydroxymethyl)piperidine-1-carboxamide
-
 Rattus norvegicus
N-[4-(trifluoromethoxy)phenyl]-1,4'-bipiperidine-1'-carboxamide
-
 Rattus norvegicus
N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
 Rattus norvegicus
N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
-
 Rattus norvegicus
N1-(2,4-dichlorobenzyl)-N4-(tetrahydro-2H-pyran-4-yl)piperidine-1,4-dicarboxamide
-
 Rattus norvegicus
N1-(2,4-dichlorobenzyl)-N4-[2-(methylsulfonyl)ethyl]piperidine-1,4-dicarboxamide
-
 Rattus norvegicus
N1-(2,4-dichlorobenzyl)-N4-[2-(pyrrolidin-1-yl)ethyl]piperidine-1,4-dicarboxamide
-
 Rattus norvegicus
N1-(2,4-dichlorobenzyl)-N4-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidine-1,4-dicarboxamide
-
 Rattus norvegicus
N1-(2,4-dichlorobenzyl)piperidine-1,4-dicarboxamide
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P80299
-
-

Synonyms

Synonyms Comment Organism
SEH
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000011
-
 4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]-piperidinecarboxamide
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000039
-
-
 Rattus norvegicus 4-(2-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
0.0000042
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[4-(methylcarbamoyl)phenoxy]piperidine-1-carboxamide
0.0000042
-
-
 Rattus norvegicus 4-(4-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
0.0000043
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-phenoxypiperidine-1-carboxamide
0.0000046
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[3-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
0.0000049
-
-
 Rattus norvegicus 4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
0.0000049
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[2-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
0.0000052
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[4-(methylsulfamoyl)phenoxy]piperidine-1-carboxamide
0.0000053
-
-
 Rattus norvegicus 4-([1-[(2,4-dichlorobenzyl)carbamoyl]piperidin-4-yl]oxy)benzoic acid
0.0000056
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.0000056
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[4-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
0.0000059
-
-
 Rattus norvegicus 4-(4-chlorophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
0.000006
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
0.0000061
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
0.000011
-
-
 Rattus norvegicus 4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.000012
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxamide
0.000012
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-(pyridin-2-ylmethyl)piperidine-1-carboxamide
0.000012
-
-
 Rattus norvegicus 3-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.000015
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide
0.000015
-
-
 Rattus norvegicus 4-benzyl-N-(2,4-dichlorobenzyl)-4-hydroxypiperidine-1-carboxamide
0.000017
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[[(4-fluorophenyl)sulfonyl]amino]piperidine-1-carboxamide
0.000018
-
-
 Rattus norvegicus 4-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.000019
-
-
 Rattus norvegicus 3-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.000024
-
-
 Rattus norvegicus N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.000027
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-hydroxy-4-phenylpiperidine-1-carboxamide
0.000029
-
-
 Rattus norvegicus 2-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.000035
-
-
 Rattus norvegicus 1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
0.000039
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-4-[(4-fluorophenyl)sulfonyl]piperidine-1-carboxamide
0.000041
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
0.000046
-
-
 Rattus norvegicus 4-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.00011
-
-
 Rattus norvegicus 2-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
0.00015
-
-
 Rattus norvegicus N1-(2,4-dichlorobenzyl)-N4-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidine-1,4-dicarboxamide
0.00018
-
-
 Rattus norvegicus N1-(2,4-dichlorobenzyl)-N4-(tetrahydro-2H-pyran-4-yl)piperidine-1,4-dicarboxamide
0.0002
-
-
 Rattus norvegicus N-(3,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
0.00021
-
-
 Rattus norvegicus N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
0.00022
-
-
 Rattus norvegicus N1-(2,4-dichlorobenzyl)-N4-[2-(pyrrolidin-1-yl)ethyl]piperidine-1,4-dicarboxamide
0.00022
-
-
 Rattus norvegicus N1-(2,4-dichlorobenzyl)piperidine-1,4-dicarboxamide
0.00023
-
-
 Rattus norvegicus N1-(2,4-dichlorobenzyl)-N4-[2-(methylsulfonyl)ethyl]piperidine-1,4-dicarboxamide
0.001
-
-
 Rattus norvegicus 1-[(2,4-dichlorobenzyl)carbamoyl]piperidine-4-carboxylic acid
0.0015
-
-
 Rattus norvegicus 3-(hydroxymethyl)-N-(2-methylbenzyl)piperidine-1-carboxamide
0.0029
-
-
 Rattus norvegicus 3-(hydroxymethyl)-N-(4-methylbenzyl)piperidine-1-carboxamide
0.003
-
-
 Rattus norvegicus N-benzyl-3-(hydroxymethyl)piperidine-1-carboxamide
0.003
-
-
 Rattus norvegicus N-[4-(trifluoromethoxy)phenyl]-1,4'-bipiperidine-1'-carboxamide
0.003
-
-
 Rattus norvegicus 3-(hydroxymethyl)-N-(1-phenylethyl)piperidine-1-carboxamide
0.003
-
-
 Rattus norvegicus 1-[[4-(trifluoromethoxy)phenyl]carbamoyl]piperidine-4-carboxylic acid
0.003
-
-
 Rattus norvegicus 3-(hydroxymethyl)-N-(3-methylbenzyl)piperidine-1-carboxamide

General Information

General Information Comment Organism
additional information inhibition of sEH leads to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects Rattus norvegicus