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Literature summary for 3.3.2.10 extracted from

  • Shen, H.C.; Ding, F.X.; Deng, Q.; Xu, S.; Tong, X.; Zhang, X.; Chen, Y.; Zhou, G.; Pai, L.Y.; Alonso-Galicia, M.; Roy, S.; Zhang, B.; Tata, J.R.; Berger, J.P.; Colletti, S.L.
    A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 5716-5721.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
 Homo sapiens
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
-
 Homo sapiens
1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
 Homo sapiens
1-cyclohexyl-3-dodecyl urea
-
 Homo sapiens
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
 Homo sapiens
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butylester
-
 Homo sapiens
4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
5-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
5-benzyl-N-phenyl-1,3,4-oxadiazol-2-amine
-
 Homo sapiens
5-phenyl-N-[4-(trifluoromethyl)benzyl]-1,2-oxazol-3-amine
-
 Homo sapiens
5-phenyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-amine
-
 Homo sapiens
6-(1H-indol-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-(2-fluorophenyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-(3-methylpyridin-2-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-(isoquinolin-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-(pyridin-3-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-(pyridin-4-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
6-phenyl-N-[3-(trifluoromethyl)benzyl]pyrimidin-4-amine
-
 Homo sapiens
6-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
7-(1H-indol-5-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl][1,2]oxazolo[5,4-c]pyridin-3-amine
-
 Homo sapiens
7-(trifluoromethyl)-N-[6-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
7-[2-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
7-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N,5-dibenzyl-1,3,4-oxadiazol-2-amine
-
 Homo sapiens
N-(biphenyl-3-yl)-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-(biphenyl-4-yl)-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-(naphthalen-1-yl)-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-(naphthalen-2-yl)-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-benzyl-1,3-benzothiazol-2-amine
-
 Homo sapiens
N-benzyl-1,3-benzoxazol-2-amine
-
 Homo sapiens
N-benzyl-4-phenylpyridin-2-amine
-
 Homo sapiens
N-benzyl-5-phenyl-1,3,4-oxadiazol-2-amine
-
 Homo sapiens
N-benzyl-5-phenylpyrazin-2-amine
-
 Homo sapiens
N-benzyl-5-phenylpyridin-2-amine
-
 Homo sapiens
N-benzylquinoxalin-2-amine
-
 Homo sapiens
N-phenyl-5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine
-
 Homo sapiens
N-[2-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-[2-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-[3-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-[3-[(2',4'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[4-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)benzyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)phenyl]-1H-indazol-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[4,5-b]pyridin-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-b]pyridin-3-amine
-
 Homo sapiens
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-c]pyridin-3-amine
-
 Homo sapiens
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000008
-
-
 Homo sapiens 12-(3-adamantan-1-yl-ureido)-dodecanoic acid butylester
0.0000013
-
-
 Homo sapiens trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
0.0000016
-
-
 Homo sapiens 1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
0.0000029
-
-
 Homo sapiens 1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
0.0000032
-
-
 Homo sapiens 12-(3-adamantan-1-yl-ureido)-dodecanoic acid
0.000004
-
-
 Homo sapiens 7-[2-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.000004
-
-
 Homo sapiens 7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.000008
-
-
 Homo sapiens 7-(1H-indol-5-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.000008
-
-
 Homo sapiens 4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.00001
-
-
 Homo sapiens 7-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.0000147
-
-
 Homo sapiens 1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
0.000018
-
-
 Homo sapiens 6-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.000019
-
-
 Homo sapiens 6-(isoquinolin-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.000019
-
-
 Homo sapiens 7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl][1,2]oxazolo[5,4-c]pyridin-3-amine
0.000023
-
-
 Homo sapiens 6-(pyridin-3-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.000025
-
-
 Homo sapiens N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.000027
-
-
 Homo sapiens N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-b]pyridin-3-amine
0.000031
-
-
 Homo sapiens N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-c]pyridin-3-amine
0.00004
-
-
 Homo sapiens 5-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.000058
-
-
 Homo sapiens 6-(pyridin-4-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.00006
-
-
 Homo sapiens N-[4-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
0.00007
-
-
 Homo sapiens 6-(1H-indol-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.00007
-
-
 Homo sapiens 6-(3-methylpyridin-2-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.000074
-
-
 Homo sapiens 7-(trifluoromethyl)-N-[6-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
0.0000852
-
-
 Homo sapiens 1-cyclohexyl-3-dodecyl urea
0.000091
-
-
 Homo sapiens 6-(2-fluorophenyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.000096
-
-
 Homo sapiens N-[2-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.00016
-
-
 Homo sapiens N-[3-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
0.00017
-
-
 Homo sapiens N-(biphenyl-4-yl)-1,2-benzoxazol-3-amine
0.00034
-
-
 Homo sapiens N-[3-[(2',4'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
0.00047
-
-
 Homo sapiens 6-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.00084
-
-
 Homo sapiens N-(naphthalen-1-yl)-1,2-benzoxazol-3-amine
0.00096
-
-
 Homo sapiens N-(biphenyl-3-yl)-1,2-benzoxazol-3-amine
0.0011
-
-
 Homo sapiens N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[4,5-b]pyridin-3-amine
0.0012
-
-
 Homo sapiens N-(naphthalen-2-yl)-1,2-benzoxazol-3-amine
0.0012
-
-
 Homo sapiens N-[4-(trifluoromethyl)benzyl]-1,2-benzoxazol-3-amine
0.002
-
-
 Homo sapiens N-phenyl-5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine
0.0025
-
-
 Homo sapiens N-[4-(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine
0.0047
-
-
 Homo sapiens 5-phenyl-N-[4-(trifluoromethyl)benzyl]-1,2-oxazol-3-amine
0.0052
-
-
 Homo sapiens N-[2-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
0.01
-
 above Homo sapiens N-benzyl-5-phenylpyridin-2-amine
0.01
-
 above Homo sapiens 5-phenyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-amine
0.01
-
 above Homo sapiens 5-benzyl-N-phenyl-1,3,4-oxadiazol-2-amine
0.01
-
 above Homo sapiens N-[4-(trifluoromethyl)phenyl]-1H-indazol-3-amine
0.01
-
 above Homo sapiens N-benzyl-5-phenyl-1,3,4-oxadiazol-2-amine
0.01
-
 above Homo sapiens N-benzyl-4-phenylpyridin-2-amine
0.01
-
 above Homo sapiens N-benzylquinoxalin-2-amine
0.01
-
 above Homo sapiens N-benzyl-1,3-benzoxazol-2-amine
0.01
-
 above Homo sapiens N,5-dibenzyl-1,3,4-oxadiazol-2-amine
0.01
-
 above Homo sapiens 6-phenyl-N-[3-(trifluoromethyl)benzyl]pyrimidin-4-amine
0.01
-
 above Homo sapiens 7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
0.01
-
 above Homo sapiens N-benzyl-5-phenylpyrazin-2-amine
0.01
-
 above Homo sapiens N-benzyl-1,3-benzothiazol-2-amine