Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one | - |
Homo sapiens | |
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one | - |
Rattus norvegicus | |
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone | - |
Homo sapiens | |
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone | - |
Rattus norvegicus | |
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone | - |
Homo sapiens | |
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone | - |
Rattus norvegicus | |
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | - |
Homo sapiens | |
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | - |
Rattus norvegicus | |
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide | - |
Homo sapiens | |
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide | - |
Rattus norvegicus | |
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
additional information | evaluation of spirocyclic secondary amine-derived trisubstituted ureas as highly potent, bioavailable and selective soluble epoxide hydrolase inhibitors, overview | Homo sapiens | |
additional information | evaluation of spirocyclic secondary amine-derived trisubstituted ureas as highly potent, bioavailable and selective soluble epoxide hydrolase inhibitors, overview | Rattus norvegicus | |
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | - |
Homo sapiens | |
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | - |
Rattus norvegicus | |
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Homo sapiens | |
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | - |
Rattus norvegicus | |
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone | - |
Homo sapiens | |
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P34913 | - |
- |
Rattus norvegicus | P80299 | spontaneously hypertensive rats | - |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Homo sapiens |
SEH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
- |
Homo sapiens | 4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000001 | - |
- |
Homo sapiens | 2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone | |
0.000002 | - |
- |
Homo sapiens | [6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone | |
0.000003 | - |
- |
Homo sapiens | 6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000003 | - |
- |
Homo sapiens | 4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000003 | - |
- |
Homo sapiens | 6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000003 | - |
- |
Homo sapiens | 4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000003 | - |
- |
Homo sapiens | 6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000004 | - |
- |
Homo sapiens | 6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000004 | - |
- |
Homo sapiens | 6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000004 | - |
- |
Homo sapiens | N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000004 | - |
- |
Homo sapiens | 3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone | |
0.000004 | - |
- |
Rattus norvegicus | 2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone | |
0.000005 | - |
- |
Homo sapiens | N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000005 | - |
- |
Homo sapiens | N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | |
0.000007 | - |
- |
Rattus norvegicus | 4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000007 | - |
- |
Homo sapiens | 1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one | |
0.000008 | - |
- |
Homo sapiens | 6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide | |
0.000008 | - |
- |
Homo sapiens | 4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000008 | - |
- |
Homo sapiens | 4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | |
0.000009 | - |
- |
Rattus norvegicus | 4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.00001 | - |
- |
Rattus norvegicus | 1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one | |
0.00001 | - |
- |
Rattus norvegicus | 3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone | |
0.000011 | - |
- |
Homo sapiens | 6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000011 | - |
- |
Homo sapiens | 6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide | |
0.000011 | - |
- |
Rattus norvegicus | N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000012 | - |
- |
Rattus norvegicus | 6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000013 | - |
- |
Rattus norvegicus | 6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000018 | - |
- |
Rattus norvegicus | 6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000019 | - |
- |
Rattus norvegicus | [6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone | |
0.00002 | - |
- |
Rattus norvegicus | 6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide | |
0.00002 | - |
- |
Homo sapiens | 4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000021 | - |
- |
Rattus norvegicus | 6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000021 | - |
- |
Rattus norvegicus | 4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000021 | - |
- |
Rattus norvegicus | N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | |
0.000023 | - |
- |
Rattus norvegicus | 6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000028 | - |
- |
Rattus norvegicus | 4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000029 | - |
- |
Rattus norvegicus | 6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000031 | - |
- |
Rattus norvegicus | 4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide | |
0.000035 | - |
- |
Rattus norvegicus | N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000039 | - |
- |
Rattus norvegicus | 4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide | |
0.000049 | - |
- |
Rattus norvegicus | 6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide |