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Literature summary for 3.3.2.10 extracted from

  • Oguro, A.; Sakamoto, K.; Suzuki, S.; Imaoka, S.
    Contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth (2009), Biol. Pharm. Bull., 32, 1962-1967.
    View publication on PubMed
Search for more literature for 3.3.2.10

Protein Variants

Protein Variants Comment Organism
D335S site-directed mutagensis, the mutant lacks epoxide hydrolase activity. The mutant looses the effects of wild-type sEH on cell growth Homo sapiens
D9A site-directed mutagensis, the mutant lacks phosphatase activity. The mutant looses the effects of wild-type sEH on cell growth Homo sapiens
additional information knockdown of sEH in He-p3B cells induces the vascular endothelial growth factor, VEGF, mRNA and cell growth, both of which are suppressed by overexpression of sEH in transfected male BALB/c mice Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
additional information Homo sapiens contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
additional information contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth, overview Homo sapiens ?
-
 ?
additional information sEH has phosphatase activity as well as epoxide hydrolase activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function sEH plays an important role in the physiology of cells including proliferation. The epoxide hydrolase and phosphatase domains of sEH have different biological functions Homo sapiens