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Literature summary for 3.3.2.10 extracted from

  • Liu, J.Y.; Yang, J.; Inceoglu, B.; Qiu, H.; Ulu, A.; Hwang, S.H.; Chiamvimonvat, N.; Hammock, B.D.
    Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model (2010), Biochem. Pharmacol., 79, 880-887.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information 129X1/SvJ x C57BL/6 background with targeted disruption of the Ephx2 gene result in Ephx2-null mice. The gene knockout affects the eicosanoid profiles of the muzants Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester i.e. AUDA-BE Mus musculus
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid i.e. t-AUCB Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epoxyeicosatrienoic acid + H2O Mus musculus
-
dihydroxyeicosatrienoic acid
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P34914 male C57BL/6 mice
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epoxyeicosatrienoic acid + H2O
-
Mus musculus dihydroxyeicosatrienoic acid
-
?

Synonyms

Synonyms Comment Organism
SEH
-
Mus musculus

General Information

General Information Comment Organism
additional information inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model, detailed overview Mus musculus