Application | Comment | Organism |
---|---|---|
pharmacology | SEH inhibition might have a potential for flow-induced vascular remodeling and neointimal formation | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Ephx2 deletion antagonizes neointimal formation in vivo in an endothelium-dependent manner | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | SEH inhibition antagonizes neointimal formation in vivo in an endothelium-dependent manner | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | SEH converts cardiovascular protective epoxyeicosatrienoic acids into less active diols attenuating the protective properties, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P80299 | male Wistar-Kyoto rats | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SEH converts cardiovascular protective epoxyeicosatrienoic acids into less active diols attenuating the protective properties, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme and vascular remodeling are associated with cardiovascular disease. Inhibition of SEH prevents smooth muscle cell proliferation in vitro and affects vascular remodeling in vivo, but induces cell proliferation in the left carotid of spontaneously hypertensive stroke-prone rats | Rattus norvegicus |