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Literature summary for 3.3.2.10 extracted from

  • Merkel, M.J.; Liu, L.; Cao, Z.; Packwood, W.; Young, J.; Alkayed, N.J.; Van Winkle, D.M.
    Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling (2010), Am. J. Physiol. Heart Circ. Physiol., 298, H679-H687.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
gene EPHX2, expression of wild-type and mutant enzymes Mus musculus

Protein Variants

Protein Variants Comment Organism
C154Y single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death Mus musculus
K55R single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death Mus musculus
additional information construction of knockout mutants of sEH, phenotypes, overview Mus musculus
R103C single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death Mus musculus
R103C/R287Q single nucleotide polymorphisms of gene EPHX2, the mutation leads to slightly reduced cell death Mus musculus
R287Q single nucleotide polymorphisms of gene EPHX2, leads to improved tolerance against ischemia in vitro, and inhibition of sEH preserves cardiomyocyte viability, mechanism, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-Phenylchalcone oxide
-
 Mus musculus
additional information sEH inhibition is abolished by STAT3 siRNA Mus musculus
N-adamantanyl-N'-dodecanoic acid urea
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus 14,15-epoxyeicosatrienoic acid, i.e. 14,15-EET, is cytoprotective in vivo, which is in part mediated by STAT3, overview (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P34914 C57BL/6J mice, gene EPHX2
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O 14,15-epoxyeicosatrienoic acid, i.e. 14,15-EET, is cytoprotective in vivo, which is in part mediated by STAT3, overview Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Mus musculus