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Literature summary for 3.3.2.10 extracted from

  • Luria, A.; Morisseau, C.; Tsai, H.J.; Yang, J.; Inceoglu, B.; De Taeye, B.; Watkins, S.M.; Wiest, M.M.; German, J.B.; Hammock, B.D.
    Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase (2009), Am. J. Physiol. Endocrinol. Metab., 297, E375-E383.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
gene ephx2 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient male mice show decreased plasma testosterone levels alongside with decreased sperm counts and testicular size, phenotype, overview. Homozygous null mice are viable and fertile and show no phenotype at birth, but progressive depeltion of germ cells in testis. Levels of cholesterol precursors lathosterol and demosterol levels are highly reduced, while stigmasterol and campesterol are unaffected, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
12[3-adamantane-1-yl-ureido]-dodecanoic acid i.e. AUDA Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epoxyeicosatrienoic acid + H2O Mus musculus
-
 dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P34914 C57BL6 mice, gene ephx2
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
plasma
-
 Mus musculus
-
sperm
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
epoxyeicosatrienoic acid + H2O
-
 Mus musculus dihydroxyeicosatrienoic acid
-
 ?
additional information sEH is bifunctional enzyme with C-terminal hydrolase and N-terminal phosphatase activities Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
EPHX2
-
 Mus musculus
SEH
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus