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Literature summary for 3.3.2.10 extracted from
- Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical (2008), Pest Manag. Sci., 64, 594-609.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| angiotensin II | induces sEH activity | Homo sapiens |  |
| peroxisome proliferator-activated receptor alpha | strong inducer of sEH | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-Phenylchalcone oxide | - |
Homo sapiens | |
| carbofuran | - |
Homo sapiens | |
| chlorpropham | - |
Homo sapiens | |
| Cyclohexene oxide | weak inhibitor | Homo sapiens | |
| dicyclohexyl urea | - |
Homo sapiens | |
| Diflubenzuron | - |
Homo sapiens | |
| diuron impurity | - |
Homo sapiens | |
| N-(1-(2,2,2-trifluoroethanoyl)piperidin-4-yl)-N'-(adamant-1-yl)urea | - |
Homo sapiens | |
| siduron | - |
Homo sapiens | |
| trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid | - |
Homo sapiens | |
| trichloropropene oxide | weak inhibitor | Homo sapiens | |
| triclocarban | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| soluble | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62500 | - |
2 * 62500 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | exceptionally high concentration in the kidney | Homo sapiens | - |
| liver | exceptionally high concentration in the liver | Homo sapiens | - |
| vascular endothelium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
| cis-stilbene oxide + H2O | - |
Homo sapiens | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| squalene oxide + H2O | weak substrate | Homo sapiens | ? | - |
? | |
| styrene oxide + H2O | very poor substrate for sEH | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 62500 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EC 3.3.2.3 | - |
Homo sapiens |
| SEH | - |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
sEH is largely inactive at basic pH values | Homo sapiens |
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Release 2023.1 (January 2023)
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