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Literature summary for 3.3.2.10 extracted from
- Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model (2008), J. Cardiovasc. Pharmacol., 52, 314-323.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease | Mus musculus |
| medicine | sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | highly potent and selective sEH inhibitor | Homo sapiens |  |
| 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | highly potent and selective sEH inhibitor | Mus musculus | |
| 12-(3-adamantan-1-yl-ureido)dodecanoic acid | potent transition state inhibitor of sEH | Homo sapiens | |
| 12-(3-adamantan-1-yl-ureido)dodecanoic acid | potent transition state inhibitor of sEH | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
| (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| 11,12-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | 5,6-hydroxyeicosatrienoic acid | - |
? | |
| 5,6-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 5,6-hydroxyeicosatrienoic acid | - |
? | |
| 8,9-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | 8,9-hydroxyeicosatrienoic acid | - |
? | |
| alpha-cyanocarbonate epoxide + H2O | - |
Mus musculus | ? | - |
? | |
| alpha-cyanocarbonate epoxide + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Mus musculus |
| SEH | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000003 | - |
purified recombinant enzyme | Homo sapiens | 12-(3-adamantan-1-yl-ureido)dodecanoic acid | |
| 0.000003 | - |
purified recombinant enzyme | Mus musculus | 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | |
| 0.00001 | - |
purified recombinant enzyme | Mus musculus | 12-(3-adamantan-1-yl-ureido)dodecanoic acid | |
| 0.000014 | - |
purified recombinant enzyme | Homo sapiens | 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea | |
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Release 2023.1 (January 2023)
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