Application | Comment | Organism |
---|---|---|
medicine | sEH is a target for the treatment of hypertension, inflammatory diseases, pain, diabetes, and stroke | Homo sapiens |
medicine | sEH is a target for the treatment of hypertension, inflammatory diseases, pain, diabetes, and stroke | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
K55R | the sEH variant K55R has increased epoxide hydrolase activity and is associated with coronary artery disease | Homo sapiens |
K55R | the sEH variant K55R has increased epoxide hydrolase activity and is associated with coronary artery disease | Mus musculus |
R287Q | the R287Q mutation results in sEH protein with reduced stability and reduced epoxide hydrolase activity, as well as decreased ability of homodimer formation | Homo sapiens |
R287Q | the R287Q mutation results in sEH protein with reduced stability and reduced epoxide hydrolase activity, as well as decreased ability of homodimer formation | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Mus musculus | 5829 | - |
peroxisome | in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal | Homo sapiens | 5777 | - |
peroxisome | in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal | Mus musculus | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | P34914 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
ovary | - |
Homo sapiens | - |
ovary | - |
Mus musculus | - |
whole body | sEH is highly expressed throughout the body | Homo sapiens | - |
whole body | sEH is highly expressed throughout the body | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Homo sapiens | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O | i.e. 5,6-EET | Homo sapiens | (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid | i.e. 5,6-DHET | ? | |
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O | i.e. 5,6-EET | Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid | i.e. 5,6-DHET | ? | |
hepoxilin A3 + H2O | excellent substrate for sEH | Homo sapiens | ? | - |
? | |
hepoxilin A3 + H2O | excellent substrate for sEH | Mus musculus | ? | - |
? | |
hepoxilin B3 + H2O | excellent substrate for sEH | Homo sapiens | ? | - |
? | |
hepoxilin B3 + H2O | excellent substrate for sEH | Mus musculus | ? | - |
? | |
leukotoxin + H2O | - |
Homo sapiens | leukotoxin diol | - |
? | |
leukotoxin + H2O | - |
Mus musculus | leukotoxin diol | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
homodimer | - |
Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
EPHX2 | - |
Homo sapiens |
EPHX2 | - |
Mus musculus |
SEH | - |
Homo sapiens |
SEH | - |
Mus musculus |