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Literature summary for 3.3.2.10 extracted from

  • Hwang, S.H.; Tsai, H.J.; Liu, J.Y.; Morisseau, C.; Hammock, B.D.
    Orally bioavailable potent soluble epoxide hydrolase inhibitors (2007), J. Med. Chem., 50, 3825-3840.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
produced in a baculovirus expression system Mus musculus
produced in a baculovirus expression system Rattus norvegicus
produced in a baculovirus expression system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Canis lupus
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Felis catus
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Homo sapiens
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Mesocricetus auratus
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Mus musculus
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea Rattus norvegicus
APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Canis lupus
APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Felis catus
APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Homo sapiens
APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Mesocricetus auratus
APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Mus musculus
APAU i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea Rattus norvegicus
AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Canis lupus
AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Felis catus
AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Homo sapiens
AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Mesocricetus auratus
AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Mus musculus
AUDA i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid Rattus norvegicus
cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
-
 Homo sapiens
cis-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
-
 Homo sapiens
cis-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
-
 Homo sapiens
cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
-
 Homo sapiens
cis-1-adamantan-1-yl-3-[4-(4-fluorophenoxy)cyclohexyl]-urea
-
 Homo sapiens
cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea
-
 Homo sapiens
cis-1-adamantan-1-yl-3-[4-(4-nitrophenoxy)cyclohexyl]urea
-
 Homo sapiens
cis-3-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Homo sapiens
cis-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)-benzoic acid
-
 Homo sapiens
trans-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
-
 Homo sapiens
trans-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
-
 Homo sapiens
trans-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
-
 Homo sapiens
trans-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
-
 Homo sapiens
trans-1-adamantan-1-yl-3-[4-(3,5-difluorophenoxy)cyclohexyl]-urea
-
 Homo sapiens
trans-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
-
 Homo sapiens
trans-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)benzoic acid
-
 Homo sapiens
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Canis lupus
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Felis catus
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Homo sapiens
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Mesocricetus auratus
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Mus musculus
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Canis lupus
-
-
-
Felis catus
-
-
-
Homo sapiens P34913
-
-
Mesocricetus auratus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
-
 Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000055
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea
0.0000006
-
 pH 7.4, 30°C Homo sapiens cis-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)-benzoic acid
0.00000072
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-nitrophenoxy)cyclohexyl]urea
0.0000009
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
0.0000009
-
 pH 7.4, 30°C Homo sapiens trans-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)benzoic acid
0.000001
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-fluorophenoxy)cyclohexyl]-urea
0.000001
-
 pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(3,5-difluorophenoxy)cyclohexyl]-urea
0.000001
-
 pH 7.5, 30°C Canis lupus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.0000011
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
0.0000013
-
 pH 7.4, 30°C Homo sapiens trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.0000013
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
0.0000015
-
 pH 7.4, 30°C Homo sapiens cis-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
0.0000016
-
 pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
0.0000017
-
 pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
0.0000017
-
 pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
0.0000017
-
 pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
0.0000017
-
 pH 7.4, 30°C Homo sapiens trans-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
0.0000019
-
 pH 7.4, 30°C Homo sapiens cis-3-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.000002
-
 pH 7.5, 30°C Mesocricetus auratus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.000002
-
 pH 7.5, 30°C Mesocricetus auratus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.000002
-
 pH 7.5, 30°C Mesocricetus auratus APAU
0.000003
-
 pH 7.4, 30°C Homo sapiens AUDA
0.000003
-
 pH 7.5, 30°C Felis catus AUDA
0.000003
-
 pH 7.5, 30°C Canis lupus AUDA
0.000003
-
 pH 7.5, 30°C Mus musculus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.000005
-
 pH 7.5, 30°C Mesocricetus auratus AUDA
0.000005
-
 pH 7.5, 30°C Rattus norvegicus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.000006
-
 pH 7.5, 30°C Felis catus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.000006
-
 pH 7.5, 30°C Rattus norvegicus APAU
0.000008
-
 pH 7.5, 30°C Mus musculus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.000008
-
 pH 7.5, 30°C Rattus norvegicus trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.000009
-
 pH 7.5, 30°C Mus musculus APAU
0.00001
-
 pH 7.5, 30°C Mus musculus AUDA
0.000011
-
 pH 7.5, 30°C Rattus norvegicus AUDA
0.000014
-
 pH 7.4, 30°C Homo sapiens 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.000015
-
 pH 7.4, 30°C Homo sapiens APAU
0.000027
-
 pH 7.5, 30°C Felis catus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.000086
-
 pH 7.5, 30°C Canis lupus 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.00045
-
 pH 7.5, 30°C Felis catus APAU
0.0005
-
 pH 7.5, 30°C Canis lupus APAU