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Literature summary for 3.3.2.10 extracted from
- Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals (1999), Toxicol. Sci., 52, 26-32.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Al3+ | 20% inhibition at 1 mM | Homo sapiens |  |
| Al3+ | 10% inhibition at 1 mM | Mus musculus | |
| Al3+ | 20% inhibition at 1 mM | Rattus norvegicus | |
| Ba2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Ba2+ | 40% inhibition at 1 mM | Mus musculus | |
| Ba2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Ca2+ | 25% inhibition at 1 mM | Homo sapiens | |
| Ca2+ | 20% inhibition at 1 mM | Mus musculus | |
| Ca2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Cd2+ | complete inhibition at 1 mM | Homo sapiens | |
| Cd2+ | complete inhibition at 1 mM | Mus musculus | |
| Cd2+ | nearly complete inhibition at 1 mM | Rattus norvegicus | |
| Cd2+ | 60% inhibition at 1 mM | Solanum tuberosum | |
| Co2+ | 30% inhibition at 1 mM | Homo sapiens | |
| Co2+ | 45% inhibition at 1 mM | Mus musculus | |
| Co2+ | 15% inhibition at 1 mM | Rattus norvegicus | |
| Co2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Cu2+ | nearly complete inhibition at 1 mM | Homo sapiens | |
| Cu2+ | complete inhibition at 1 mM | Mus musculus | |
| Cu2+ | over 95% inhibition at 1 mM | Rattus norvegicus | |
| Cu2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Fe2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Fe2+ | 10% inhibition at 1 mM | Rattus norvegicus | |
| Fe3+ | 15% inhibition at 1 mM | Homo sapiens | |
| Fe3+ | 20% inhibition at 1 mM | Rattus norvegicus | |
| Hg2+ | complete inhibition at 1 mM | Homo sapiens | |
| Hg2+ | complete inhibition at 1 mM | Mus musculus | |
| Hg2+ | complete inhibition at 1 mM | Rattus norvegicus | |
| Hg2+ | 70% inhibition at 1 mM | Solanum tuberosum | |
| Mg2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Mg2+ | 30% inhibition at 1 mM | Mus musculus | |
| Mg2+ | 40% inhibition at 1 mM | Solanum tuberosum | |
| Mn2+ | 30% inhibition at 1 mM | Homo sapiens | |
| Mn2+ | 20% inhibition at 1 mM | Mus musculus | |
| Mn2+ | 20% inhibition at 1 mM | Solanum tuberosum | |
| additional information | metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions | Homo sapiens | |
| additional information | no inhibition by Fe2+ and Fe3+ at 1 mM, metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions | Mus musculus | |
| additional information | no inhibition by Mn2+, Ba2+, Mg2+, and Ca2+ at 1 mM, metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions | Rattus norvegicus | |
| additional information | metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions | Solanum tuberosum | |
| Ni2+ | 25% inhibition at 1 mM | Homo sapiens | |
| Ni2+ | 40% inhibition at 1 mM | Mus musculus | |
| Ni2+ | 20% inhibition at 1 mM | Rattus norvegicus | |
| Ni2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Pb2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Pb2+ | 30% inhibition at 1 mM | Mus musculus | |
| Pb2+ | 25% inhibition at 1 mM | Rattus norvegicus | |
| Pb2+ | 60% inhibition at 1 mM | Solanum tuberosum | |
| Zn2+ | complete inhibition at 1 mM | Homo sapiens | |
| Zn2+ | complete inhibition at 1 mM | Mus musculus | |
| Zn2+ | over 95% inhibition at 1 mM | Rattus norvegicus | |
| Zn2+ | 40% inhibition at 1 mM | Solanum tuberosum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0078 | - |
trans-diphenylpropene oxide | pH 7.4, 37°C | Mus musculus | |
| 0.0081 | - |
trans-diphenylpropene oxide | pH 7.4, 37°C | Homo sapiens | |
| 0.01 | - |
trans-diphenylpropene oxide | pH 7.4, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Solanum tuberosum | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Al3+ | 10% inhibition at 1 mM | Mus musculus | |
| Al3+ | 20% inhibition at 1 mM | Homo sapiens | |
| Al3+ | 20% inhibition at 1 mM | Rattus norvegicus | |
| Al3+ | 35%% activation at 1 mM | Solanum tuberosum | |
| Ba2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Ba2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Ba2+ | 40% inhibition at 1 mM | Mus musculus | |
| Ca2+ | 20% inhibition at 1 mM | Mus musculus | |
| Ca2+ | 25% inhibition at 1 mM | Homo sapiens | |
| Ca2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Cd2+ | complete inhibition at 1 mM | Mus musculus | |
| Cd2+ | complete inhibition at 1 mM | Homo sapiens | |
| Cd2+ | 60% inhibition at 1 mM | Solanum tuberosum | |
| Cd2+ | nearly complete inhibition at 1 mM | Rattus norvegicus | |
| Co2+ | 15% inhibition at 1 mM | Rattus norvegicus | |
| Co2+ | 30% inhibition at 1 mM | Homo sapiens | |
| Co2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Co2+ | 45% inhibition at 1 mM | Mus musculus | |
| Cu2+ | complete inhibition at 1 mM | Mus musculus | |
| Cu2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Cu2+ | nearly complete inhibition at 1 mM | Homo sapiens | |
| Cu2+ | over 95% inhibition at 1 mM | Rattus norvegicus | |
| Fe2+ | 10% activation at 1 mM | Mus musculus | |
| Fe2+ | 10% inhibition at 1 mM | Rattus norvegicus | |
| Fe2+ | 15%% activation at 1 mM | Solanum tuberosum | |
| Fe2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Fe3+ | 15% inhibition at 1 mM | Homo sapiens | |
| Fe3+ | 20% inhibition at 1 mM | Rattus norvegicus | |
| Fe3+ | 30%% activation at 1 mM | Solanum tuberosum | |
| Hg2+ | complete inhibition at 1 mM | Mus musculus | |
| Hg2+ | complete inhibition at 1 mM | Homo sapiens | |
| Hg2+ | complete inhibition at 1 mM | Rattus norvegicus | |
| Hg2+ | 70% inhibition at 1 mM | Solanum tuberosum | |
| Mg2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Mg2+ | 30% inhibition at 1 mM | Mus musculus | |
| Mg2+ | 40% inhibition at 1 mM | Solanum tuberosum | |
| Mn2+ | 20% inhibition at 1 mM | Mus musculus | |
| Mn2+ | 20% inhibition at 1 mM | Solanum tuberosum | |
| Mn2+ | 30% inhibition at 1 mM | Homo sapiens | |
| additional information | no effect on activity by 1 mM Fe3+ | Mus musculus | |
| additional information | no effect on activity by 1 mM Mg2+, Ca2+, and Ba2+ | Rattus norvegicus | |
| Ni2+ | 20% inhibition at 1 mM | Rattus norvegicus | |
| Ni2+ | 25% inhibition at 1 mM | Homo sapiens | |
| Ni2+ | 30% inhibition at 1 mM | Solanum tuberosum | |
| Ni2+ | 40% inhibition at 1 mM | Mus musculus | |
| Pb2+ | 20% inhibition at 1 mM | Homo sapiens | |
| Pb2+ | 25% inhibition at 1 mM | Rattus norvegicus | |
| Pb2+ | 30% inhibition at 1 mM | Mus musculus | |
| Pb2+ | 60% inhibition at 1 mM | Solanum tuberosum | |
| Zn2+ | complete inhibition at 1 mM | Mus musculus | |
| Zn2+ | complete inhibition at 1 mM | Homo sapiens | |
| Zn2+ | 40% inhibition at 1 mM | Solanum tuberosum | |
| Zn2+ | over 95% inhibition at 1 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
male Swiss Webster mice | - |
| Rattus norvegicus | - |
male F344 rats | - |
| Solanum tuberosum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans-diphenylpropene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
| trans-diphenylpropene oxide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| trans-diphenylpropene oxide + H2O | recombinant enzyme | Mus musculus | ? | - |
? | |
| trans-diphenylpropene oxide + H2O | recombinant enzyme | Solanum tuberosum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Mus musculus |
| SEH | - |
Homo sapiens |
| SEH | - |
Rattus norvegicus |
| SEH | - |
Solanum tuberosum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Solanum tuberosum |
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Homo sapiens |
| 7.4 | - |
assay at | Rattus norvegicus |
| 7.4 | - |
assay at | Solanum tuberosum |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00058 | - |
Zn2+ | pH 7.4, 37°C, recombinant enzyme, uncompetitive inhibition type | Mus musculus | |
| 0.023 | - |
Zn2+ | pH 7.4, 37°C, noncompetitive inhibition type | Homo sapiens | |
| 0.62 | - |
Zn2+ | pH 7.4, 37°C, recombinant enzyme, noncompetitive inhibition type | Solanum tuberosum | |
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