BRENDA - Enzyme Database show
show all sequences of 3.3.2.10

Epoxide hydrolases: their roles and interactions with lipid metabolism

Newman, J.W.; Morisseau, C.; Hammock, B.D.; Prog. Lipid Res. 44, 1-51 (2005)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Ananas comosus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Apium graveolens
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, while auxin, 2,4-dichlorophenoxy acetic acid, and naphthalene acetic acid induce the enzyme in stem and leaves, drought stress slightly induces the enzmye in stem and leaves
Arabidopsis thaliana
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Brassica napus
additional information
the enzyme is induced by clofibrate
Cavia porcellus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, pathogenic fungus infection induces the enzyme in leaves
Citrus jambhiri
additional information
the enzyme is induced by clofibrate
Equus caballus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Euphorbia lagascae
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, ethylene induces the enzyme in germinating seeds
Glycine max
additional information
the enzyme is induced by clofibrate
Homo sapiens
additional information
the enzyme is induced by clofibrate
Macaca mulatta
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Malus pumila
additional information
the enzyme is induced by clofibrate
Mesocricetus auratus
additional information
the enzyme is induced by clofibrate
Mus musculus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, viral infection of the aerial body and the plant induces the enzyme
Nicotiana tabacum
additional information
the enzyme is induced by clofibrate
Oryctolagus cuniculus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Oryza sativa
additional information
the enzyme is induced by clofibrate
Papio sp.
additional information
the enzyme is induced by clofibrate
Rattus norvegicus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Ricinus communis
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, but highly by methyl jasmonate, auxin, and ethylene, wounding induces the enzyme in leaves
Solanum tuberosum
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Spinacia oleracea
additional information
the enzyme is induced by clofibrate
Sus scrofa
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Triticum aestivum
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Vicia sativa
Engineering
Amino acid exchange
Commentary
Organism
additional information
enzyme polymorphisms, overview
Homo sapiens
R287E
naturally occuring mutation of gene EPXH2 leads to elevated plasma cholesterol and triglycerides
Homo sapiens
R287Q
naturally occuring mutation of gene EPXH2 leads to elevated risk of coronary artery calcification found in African Americans
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Ananas comosus
5829
-
cytosol
-
Apium graveolens
5829
-
cytosol
-
Arabidopsis thaliana
5829
-
cytosol
-
Brassica napus
5829
-
cytosol
-
Cavia porcellus
5829
-
cytosol
-
Citrus jambhiri
5829
-
cytosol
-
Equus caballus
5829
-
cytosol
-
Euphorbia lagascae
5829
-
cytosol
-
Glycine max
5829
-
cytosol
-
Macaca mulatta
5829
-
cytosol
-
Malus pumila
5829
-
cytosol
-
Mesocricetus auratus
5829
-
cytosol
-
Nicotiana tabacum
5829
-
cytosol
-
Oncorhynchus mykiss
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
cytosol
-
Oryza sativa
5829
-
cytosol
-
Oryzias latipes
5829
-
cytosol
-
Papio sp.
5829
-
cytosol
-
Pimephales promelas
5829
-
cytosol
-
Ricinus communis
5829
-
cytosol
-
Spinacia oleracea
5829
-
cytosol
-
Stenotomus chrysops
5829
-
cytosol
-
Sus scrofa
5829
-
cytosol
-
Triticum aestivum
5829
-
cytosol
-
Vicia sativa
5829
-
cytosol
-
Zea mays
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Solanum tuberosum
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Homo sapiens
5829
-
glyoxysome
-
Ricinus communis
9514
-
peroxisome
in the light mitochondrial fraction
Mus musculus
5777
-
peroxisome
the enzyme contains an impaired peroxisomal targeting sequence leading to dual localization
Rattus norvegicus
5777
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
x * 35000, about
Ananas comosus
35000
-
x * 35000, about
Apium graveolens
35000
-
n * 35000, about
Arabidopsis thaliana
35000
-
x * 35000, about
Brassica napus
35000
-
x * 35000, about
Citrus jambhiri
35000
-
x * 35000, about
Euphorbia lagascae
35000
-
n * 35000, about
Glycine max
35000
-
x * 35000, about
Malus pumila
35000
-
x * 35000, about
Nicotiana tabacum
35000
-
x * 35000, about
Oryza sativa
35000
-
n * 35000, about
Ricinus communis
35000
-
n * 35000, about
Solanum tuberosum
35000
-
x * 35000, about
Spinacia oleracea
35000
-
x * 35000, about
Triticum aestivum
35000
-
x * 35000, about
Vicia sativa
62000
-
2 * 62000, about
Cavia porcellus
62000
-
2 * 62000, about
Equus caballus
62000
-
2 * 62000, about
Homo sapiens
62000
-
2 * 62000, about
Macaca mulatta
62000
-
2 * 62000, about
Mesocricetus auratus
62000
-
2 * 62000, about
Mus musculus
62000
-
2 * 62000, about
Oryctolagus cuniculus
62000
-
2 * 62000, about
Papio sp.
62000
-
2 * 62000, about
Rattus norvegicus
62000
-
2 * 62000, about
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
Solanum tuberosum
-
?
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
Citrus jambhiri
-
?
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
Malus pumila
step in cutin biosynthesis
?
-
-
?
additional information
Homo sapiens
enzyme regulation, overview
?
-
-
-
additional information
Oncorhynchus mykiss
enzyme regulation, overview
?
-
-
-
additional information
Oryzias latipes
enzyme regulation, overview
?
-
-
-
additional information
Pimephales promelas
enzyme regulation, overview
?
-
-
-
additional information
Stenotomus chrysops
enzyme regulation, overview
?
-
-
-
additional information
Vicia sativa
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Triticum aestivum
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Spinacia oleracea
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Zea mays
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Nicotiana tabacum
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Glycine max
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Arabidopsis thaliana
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Brassica napus
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Ricinus communis
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Apium graveolens
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Oryza sativa
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Ananas comosus
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Euphorbia lagascae
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Malus pumila
synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Citrus jambhiri
the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Solanum tuberosum
the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Cavia porcellus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Rattus norvegicus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Sus scrofa
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Oryctolagus cuniculus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Mesocricetus auratus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Equus caballus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Macaca mulatta
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Papio sp.
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Mus musculus
the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Ananas comosus
-
multiple isozymes, constitutive and inducible
-
Apium graveolens
-
multiple isozymes, constitutive and inducible
-
Arabidopsis thaliana
-
multiple isozymes, constitutive and inducible
-
Brassica napus
-
multiple isozymes, constitutive and inducible
-
Cavia porcellus
-
-
-
Citrus jambhiri
-
multiple isozymes, constitutive and inducible
-
Equus caballus
-
-
-
Euphorbia lagascae
-
multiple isozymes, constitutive and inducible
-
Glycine max
-
multiple isozymes, constitutive and inducible
-
Homo sapiens
-
-
-
Macaca mulatta
-
-
-
Malus pumila
-
multiple isozymes, constitutive and inducible
-
Mesocricetus auratus
-
-
-
Nicotiana tabacum
-
multiple isozymes, constitutive and infection-induced
-
Oncorhynchus mykiss
-
-
-
Oryctolagus cuniculus
-
-
-
Oryza sativa
-
multiple isozymes, constitutive and inducible
-
Oryzias latipes
-
-
-
Papio sp.
-
baboon
-
Pimephales promelas
-
-
-
Rattus norvegicus
-
-
-
Ricinus communis
-
multiple isozymes, constitutive and inducible
-
Solanum tuberosum
-
multiple isozymes, constitutive and inducible
-
Spinacia oleracea
-
multiple isozymes, constitutive and inducible
-
Stenotomus chrysops
-
-
-
Sus scrofa
-
-
-
Triticum aestivum
-
multiple isozymes, constitutive and inducible
-
Vicia sativa
-
multiple isozymes, constitutive and inducible
-
Zea mays
-
multiple isozymes
-
Mus musculus
P34914
isozyme EPXH2B
-
Purification (Commentary)
Commentary
Organism
from liver
Cavia porcellus
from liver
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Homo sapiens
-
aerial part
-
Nicotiana tabacum
-
brain
-
Rattus norvegicus
-
endosperm
-
Ricinus communis
-
endothelium
vascular
Homo sapiens
-
epididymis
-
Homo sapiens
-
fruit
-
Malus pumila
-
gonad
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
intestine
-
Homo sapiens
-
kidney
cortex
Homo sapiens
-
kidney
cortex
Mus musculus
-
kidney
cortex
Rattus norvegicus
-
leaf
-
Arabidopsis thaliana
-
leaf
-
Citrus jambhiri
-
leaf
-
Nicotiana tabacum
-
leaf
meristem shows increased enzyme level compared to expanding and mature leaves
Solanum tuberosum
-
leukocyte
-
Rattus norvegicus
-
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
lymph node
-
Homo sapiens
-
mammary gland
-
Mus musculus
-
additional information
tissue distribution
Ananas comosus
-
additional information
tissue distribution
Apium graveolens
-
additional information
tissue distribution
Arabidopsis thaliana
-
additional information
tissue distribution
Brassica napus
-
additional information
tissue distribution
Cavia porcellus
-
additional information
tissue distribution
Citrus jambhiri
-
additional information
tissue distribution
Equus caballus
-
additional information
tissue distribution
Euphorbia lagascae
-
additional information
tissue distribution
Glycine max
-
additional information
tissue distribution
Homo sapiens
-
additional information
tissue distribution
Macaca mulatta
-
additional information
tissue distribution
Malus pumila
-
additional information
tissue distribution
Mesocricetus auratus
-
additional information
tissue distribution
Mus musculus
-
additional information
tissue distribution
Nicotiana tabacum
-
additional information
tissue distribution
Oncorhynchus mykiss
-
additional information
tissue distribution
Oryctolagus cuniculus
-
additional information
tissue distribution
Oryza sativa
-
additional information
tissue distribution
Oryzias latipes
-
additional information
tissue distribution
Papio sp.
-
additional information
tissue distribution
Pimephales promelas
-
additional information
tissue distribution
Rattus norvegicus
-
additional information
tissue distribution
Ricinus communis
-
additional information
tissue distribution
Solanum tuberosum
-
additional information
tissue distribution
Spinacia oleracea
-
additional information
tissue distribution
Stenotomus chrysops
-
additional information
tissue distribution
Sus scrofa
-
additional information
tissue distribution
Triticum aestivum
-
additional information
tissue distribution
Vicia sativa
-
additional information
tissue distribution
Zea mays
-
muscle
striated
Mus musculus
-
ovary
-
Homo sapiens
-
ovary
-
Mus musculus
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate
-
Homo sapiens
-
seed
germination-specific isozyme
Euphorbia lagascae
-
seed
germinating
Glycine max
-
skin
-
Rattus norvegicus
-
smooth muscle
-
Homo sapiens
-
spleen
-
Rattus norvegicus
-
stem
-
Arabidopsis thaliana
-
stomach
-
Homo sapiens
-
testis
-
Rattus norvegicus
-
tonsil
-
Homo sapiens
-
urinary bladder
-
Homo sapiens
-
uterus
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11,12-leukotriene A4 + H2O
-
663275
Cavia porcellus
?
-
-
-
?
11R,12S-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
11R,12S-dihydroxyeicosatrienoic acid
-
-
-
?
11S,12R-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
11S,12R-hydroxyeicosatrienoic acid
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Triticum aestivum
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Zea mays
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Solanum tuberosum
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Nicotiana tabacum
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Glycine max
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Apium graveolens
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Oryza sativa
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
14,15-leukotriene A4 + H2O
-
663275
Cavia porcellus
?
-
-
-
?
14R,15S-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
14R,15S-dihydroxyeicosatrienoic acid
-
-
-
?
14S,15R-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
14S,15R-dihydroxyeicosatrienoic acid
-
-
-
?
14S,15S-trans-epoxy-(5Z,8Z,10E,12E)-eicosatrienoic acid + H2O
-
663275
Mus musculus
14S,15R-dihydroxyeicosatrienoic acid
-
-
-
?
5,6-leukotriene A4 + H2O
-
663275
Cavia porcellus
?
-
-
-
?
8R,9S-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
8R,9S-dihydroxyeicosatrienoic acid
-
-
-
?
8S,9R-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
8S,9R-dihydroxyeicosatrienoic acid
-
-
-
?
9(10),12(13)-diepoxyoctadecanoic acid + H2O
-
663275
Mus musculus
9,10,12,13-tetrahydroxyoctadecanoic acid
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity
663275
Triticum aestivum
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity
663275
Zea mays
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity
663275
Oryza sativa
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity of infection-induced isozymes, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
663275
Nicotiana tabacum
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
the enzyme prefers the (9R,10S)-enantiomer
663275
Apium graveolens
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
the enzyme prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
663275
Solanum tuberosum
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
the enzyme strongly prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
663275
Glycine max
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Triticum aestivum
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Zea mays
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Solanum tuberosum
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Nicotiana tabacum
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Glycine max
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Apium graveolens
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Oryza sativa
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
step in cutin biosynthesis
663275
Malus pumila
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Triticum aestivum
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Zea mays
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Solanum tuberosum
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Nicotiana tabacum
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Glycine max
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Apium graveolens
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Oryza sativa
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
additional information
enzyme regulation, overview
663275
Homo sapiens
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Oncorhynchus mykiss
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Oryzias latipes
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Pimephales promelas
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Stenotomus chrysops
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Vicia sativa
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Triticum aestivum
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Spinacia oleracea
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Zea mays
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Nicotiana tabacum
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Glycine max
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Arabidopsis thaliana
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Brassica napus
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Ricinus communis
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Apium graveolens
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Oryza sativa
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Ananas comosus
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Euphorbia lagascae
?
-
-
-
-
additional information
synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Malus pumila
?
-
-
-
-
additional information
the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Citrus jambhiri
?
-
-
-
-
additional information
the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Solanum tuberosum
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Cavia porcellus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Rattus norvegicus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Sus scrofa
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Oryctolagus cuniculus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Mesocricetus auratus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Equus caballus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Macaca mulatta
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview
663275
Papio sp.
?
-
-
-
-
additional information
the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview
663275
Mus musculus
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Vicia sativa
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Triticum aestivum
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Spinacia oleracea
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Zea mays
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Solanum tuberosum
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Nicotiana tabacum
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Glycine max
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Arabidopsis thaliana
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Brassica napus
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Ricinus communis
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Apium graveolens
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Oryza sativa
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Ananas comosus
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Euphorbia lagascae
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Citrus jambhiri
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Malus pumila
?
-
-
-
-
additional information
substrate specificity, the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, except for the isozyme EPXH2B, overview
663275
Mus musculus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Cavia porcellus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Sus scrofa
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Oryctolagus cuniculus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Mesocricetus auratus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Equus caballus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Macaca mulatta
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Papio sp.
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview
663275
Homo sapiens
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview
663275
Rattus norvegicus
?
-
-
-
-
squalene diepoxide + H2O
-
663275
Mus musculus
?
-
-
-
?
squalene-2,3-epoxide + H2O
-
663275
Mus musculus
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 62000, about
Cavia porcellus
dimer
2 * 62000, about
Equus caballus
dimer
2 * 62000, about
Homo sapiens
dimer
2 * 62000, about
Macaca mulatta
dimer
2 * 62000, about
Mesocricetus auratus
dimer
2 * 62000, about
Mus musculus
dimer
2 * 62000, about
Oryctolagus cuniculus
dimer
2 * 62000, about
Papio sp.
dimer
2 * 62000, about
Rattus norvegicus
dimer
2 * 62000, about
Sus scrofa
monomer or dimer
x * 35000, about
Ananas comosus
monomer or dimer
x * 35000, about
Apium graveolens
monomer or dimer
n * 35000, about
Arabidopsis thaliana
monomer or dimer
x * 35000, about
Brassica napus
monomer or dimer
x * 35000, about
Citrus jambhiri
monomer or dimer
x * 35000, about
Euphorbia lagascae
monomer or dimer
n * 35000, about
Glycine max
monomer or dimer
x * 35000, about
Malus pumila
monomer or dimer
x * 35000, about
Nicotiana tabacum
monomer or dimer
x * 35000, about
Oryza sativa
monomer or dimer
n * 35000, about
Ricinus communis
monomer or dimer
n * 35000, about
Solanum tuberosum
monomer or dimer
x * 35000, about
Spinacia oleracea
monomer or dimer
x * 35000, about
Triticum aestivum
monomer or dimer
x * 35000, about
Vicia sativa
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Cavia porcellus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Equus caballus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Homo sapiens
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Macaca mulatta
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Mesocricetus auratus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Mus musculus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Oryctolagus cuniculus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Papio sp.
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Rattus norvegicus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Sus scrofa
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Cavia porcellus
-
6
5
Equus caballus
-
6
5
Macaca mulatta
-
6
5
Mesocricetus auratus
-
6
5
Oryctolagus cuniculus
-
6
5
Rattus norvegicus
-
6
5
Sus scrofa
-
6
5
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Ananas comosus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Apium graveolens
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, while auxin, 2,4-dichlorophenoxy acetic acid, and naphthalene acetic acid induce the enzyme in stem and leaves, drought stress slightly induces the enzmye in stem and leaves
Arabidopsis thaliana
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Brassica napus
additional information
the enzyme is induced by clofibrate
Cavia porcellus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, pathogenic fungus infection induces the enzyme in leaves
Citrus jambhiri
additional information
the enzyme is induced by clofibrate
Equus caballus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Euphorbia lagascae
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, ethylene induces the enzyme in germinating seeds
Glycine max
additional information
the enzyme is induced by clofibrate
Homo sapiens
additional information
the enzyme is induced by clofibrate
Macaca mulatta
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Malus pumila
additional information
the enzyme is induced by clofibrate
Mesocricetus auratus
additional information
the enzyme is induced by clofibrate
Mus musculus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth, viral infection of the aerial body and the plant induces the enzyme
Nicotiana tabacum
additional information
the enzyme is induced by clofibrate
Oryctolagus cuniculus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Oryza sativa
additional information
the enzyme is induced by clofibrate
Papio sp.
additional information
the enzyme is induced by clofibrate
Rattus norvegicus
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Ricinus communis
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, growth, the enzyme is not affected by cytokinin, abscisic acid, 6-benzylaminopurine, or gibberellin, but highly by methyl jasmonate, auxin, and ethylene, wounding induces the enzyme in leaves
Solanum tuberosum
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Spinacia oleracea
additional information
the enzyme is induced by clofibrate
Sus scrofa
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Triticum aestivum
additional information
inducible isozymes can be induced by e.g. fruit ripening, germination, host-defense, exogenous exposure to hormones, growth
Vicia sativa
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
enzyme polymorphisms, overview
Homo sapiens
R287E
naturally occuring mutation of gene EPXH2 leads to elevated plasma cholesterol and triglycerides
Homo sapiens
R287Q
naturally occuring mutation of gene EPXH2 leads to elevated risk of coronary artery calcification found in African Americans
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Ananas comosus
5829
-
cytosol
-
Apium graveolens
5829
-
cytosol
-
Arabidopsis thaliana
5829
-
cytosol
-
Brassica napus
5829
-
cytosol
-
Cavia porcellus
5829
-
cytosol
-
Citrus jambhiri
5829
-
cytosol
-
Equus caballus
5829
-
cytosol
-
Euphorbia lagascae
5829
-
cytosol
-
Glycine max
5829
-
cytosol
-
Macaca mulatta
5829
-
cytosol
-
Malus pumila
5829
-
cytosol
-
Mesocricetus auratus
5829
-
cytosol
-
Nicotiana tabacum
5829
-
cytosol
-
Oncorhynchus mykiss
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
cytosol
-
Oryza sativa
5829
-
cytosol
-
Oryzias latipes
5829
-
cytosol
-
Papio sp.
5829
-
cytosol
-
Pimephales promelas
5829
-
cytosol
-
Ricinus communis
5829
-
cytosol
-
Spinacia oleracea
5829
-
cytosol
-
Stenotomus chrysops
5829
-
cytosol
-
Sus scrofa
5829
-
cytosol
-
Triticum aestivum
5829
-
cytosol
-
Vicia sativa
5829
-
cytosol
-
Zea mays
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Solanum tuberosum
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Mus musculus
5829
-
glyoxysome
-
Ricinus communis
9514
-
peroxisome
in the light mitochondrial fraction
Mus musculus
5777
-
peroxisome
the enzyme contains an impaired peroxisomal targeting sequence leading to dual localization
Rattus norvegicus
5777
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
x * 35000, about
Ananas comosus
35000
-
x * 35000, about
Apium graveolens
35000
-
n * 35000, about
Arabidopsis thaliana
35000
-
x * 35000, about
Brassica napus
35000
-
x * 35000, about
Citrus jambhiri
35000
-
x * 35000, about
Euphorbia lagascae
35000
-
n * 35000, about
Glycine max
35000
-
x * 35000, about
Malus pumila
35000
-
x * 35000, about
Nicotiana tabacum
35000
-
x * 35000, about
Oryza sativa
35000
-
n * 35000, about
Ricinus communis
35000
-
n * 35000, about
Solanum tuberosum
35000
-
x * 35000, about
Spinacia oleracea
35000
-
x * 35000, about
Triticum aestivum
35000
-
x * 35000, about
Vicia sativa
62000
-
2 * 62000, about
Cavia porcellus
62000
-
2 * 62000, about
Equus caballus
62000
-
2 * 62000, about
Homo sapiens
62000
-
2 * 62000, about
Macaca mulatta
62000
-
2 * 62000, about
Mesocricetus auratus
62000
-
2 * 62000, about
Mus musculus
62000
-
2 * 62000, about
Oryctolagus cuniculus
62000
-
2 * 62000, about
Papio sp.
62000
-
2 * 62000, about
Rattus norvegicus
62000
-
2 * 62000, about
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
Solanum tuberosum
-
?
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
Citrus jambhiri
-
?
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
Malus pumila
step in cutin biosynthesis
?
-
-
?
additional information
Homo sapiens
enzyme regulation, overview
?
-
-
-
additional information
Oncorhynchus mykiss
enzyme regulation, overview
?
-
-
-
additional information
Oryzias latipes
enzyme regulation, overview
?
-
-
-
additional information
Pimephales promelas
enzyme regulation, overview
?
-
-
-
additional information
Stenotomus chrysops
enzyme regulation, overview
?
-
-
-
additional information
Vicia sativa
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Triticum aestivum
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Spinacia oleracea
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Zea mays
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Nicotiana tabacum
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Glycine max
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Arabidopsis thaliana
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Brassica napus
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Ricinus communis
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Apium graveolens
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Oryza sativa
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Ananas comosus
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Euphorbia lagascae
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Malus pumila
synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Citrus jambhiri
the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Solanum tuberosum
the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
?
-
-
-
additional information
Cavia porcellus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Rattus norvegicus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Sus scrofa
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Oryctolagus cuniculus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Mesocricetus auratus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Equus caballus
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Macaca mulatta
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Papio sp.
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview
?
-
-
-
additional information
Mus musculus
the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
from liver
Cavia porcellus
from liver
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Homo sapiens
-
aerial part
-
Nicotiana tabacum
-
brain
-
Rattus norvegicus
-
endosperm
-
Ricinus communis
-
endothelium
vascular
Homo sapiens
-
epididymis
-
Homo sapiens
-
fruit
-
Malus pumila
-
gonad
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
intestine
-
Homo sapiens
-
kidney
cortex
Homo sapiens
-
kidney
cortex
Mus musculus
-
kidney
cortex
Rattus norvegicus
-
leaf
-
Arabidopsis thaliana
-
leaf
-
Citrus jambhiri
-
leaf
-
Nicotiana tabacum
-
leaf
meristem shows increased enzyme level compared to expanding and mature leaves
Solanum tuberosum
-
leukocyte
-
Rattus norvegicus
-
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
lymph node
-
Homo sapiens
-
mammary gland
-
Mus musculus
-
additional information
tissue distribution
Ananas comosus
-
additional information
tissue distribution
Apium graveolens
-
additional information
tissue distribution
Arabidopsis thaliana
-
additional information
tissue distribution
Brassica napus
-
additional information
tissue distribution
Cavia porcellus
-
additional information
tissue distribution
Citrus jambhiri
-
additional information
tissue distribution
Equus caballus
-
additional information
tissue distribution
Euphorbia lagascae
-
additional information
tissue distribution
Glycine max
-
additional information
tissue distribution
Homo sapiens
-
additional information
tissue distribution
Macaca mulatta
-
additional information
tissue distribution
Malus pumila
-
additional information
tissue distribution
Mesocricetus auratus
-
additional information
tissue distribution
Mus musculus
-
additional information
tissue distribution
Nicotiana tabacum
-
additional information
tissue distribution
Oncorhynchus mykiss
-
additional information
tissue distribution
Oryctolagus cuniculus
-
additional information
tissue distribution
Oryza sativa
-
additional information
tissue distribution
Oryzias latipes
-
additional information
tissue distribution
Papio sp.
-
additional information
tissue distribution
Pimephales promelas
-
additional information
tissue distribution
Rattus norvegicus
-
additional information
tissue distribution
Ricinus communis
-
additional information
tissue distribution
Solanum tuberosum
-
additional information
tissue distribution
Spinacia oleracea
-
additional information
tissue distribution
Stenotomus chrysops
-
additional information
tissue distribution
Sus scrofa
-
additional information
tissue distribution
Triticum aestivum
-
additional information
tissue distribution
Vicia sativa
-
additional information
tissue distribution
Zea mays
-
muscle
striated
Mus musculus
-
ovary
-
Mus musculus
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate
-
Homo sapiens
-
seed
germination-specific isozyme
Euphorbia lagascae
-
seed
germinating
Glycine max
-
skin
-
Rattus norvegicus
-
smooth muscle
-
Homo sapiens
-
spleen
-
Rattus norvegicus
-
stem
-
Arabidopsis thaliana
-
stomach
-
Homo sapiens
-
testis
-
Rattus norvegicus
-
tonsil
-
Homo sapiens
-
urinary bladder
-
Homo sapiens
-
uterus
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11,12-leukotriene A4 + H2O
-
663275
Cavia porcellus
?
-
-
-
?
11R,12S-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
11R,12S-dihydroxyeicosatrienoic acid
-
-
-
?
11S,12R-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
11S,12R-hydroxyeicosatrienoic acid
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Triticum aestivum
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Zea mays
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Solanum tuberosum
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Nicotiana tabacum
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Glycine max
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Apium graveolens
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Oryza sativa
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
14,15-leukotriene A4 + H2O
-
663275
Cavia porcellus
?
-
-
-
?
14R,15S-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
14R,15S-dihydroxyeicosatrienoic acid
-
-
-
?
14S,15R-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
14S,15R-dihydroxyeicosatrienoic acid
-
-
-
?
14S,15S-trans-epoxy-(5Z,8Z,10E,12E)-eicosatrienoic acid + H2O
-
663275
Mus musculus
14S,15R-dihydroxyeicosatrienoic acid
-
-
-
?
5,6-leukotriene A4 + H2O
-
663275
Cavia porcellus
?
-
-
-
?
8R,9S-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
8R,9S-dihydroxyeicosatrienoic acid
-
-
-
?
8S,9R-epoxyeicosatrienoic acid + H2O
-
663275
Mus musculus
8S,9R-dihydroxyeicosatrienoic acid
-
-
-
?
9(10),12(13)-diepoxyoctadecanoic acid + H2O
-
663275
Mus musculus
9,10,12,13-tetrahydroxyoctadecanoic acid
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity
663275
Triticum aestivum
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity
663275
Zea mays
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity
663275
Oryza sativa
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
no enantioselectivity of infection-induced isozymes, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
663275
Nicotiana tabacum
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
the enzyme prefers the (9R,10S)-enantiomer
663275
Apium graveolens
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
the enzyme prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
663275
Solanum tuberosum
?
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
the enzyme strongly prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
663275
Glycine max
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Triticum aestivum
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Zea mays
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Solanum tuberosum
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Nicotiana tabacum
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Glycine max
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Apium graveolens
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Oryza sativa
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
step in cutin biosynthesis
663275
Malus pumila
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Vicia sativa
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Triticum aestivum
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Spinacia oleracea
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Zea mays
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Solanum tuberosum
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Nicotiana tabacum
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Glycine max
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Arabidopsis thaliana
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Brassica napus
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ricinus communis
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Apium graveolens
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Oryza sativa
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Ananas comosus
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Euphorbia lagascae
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Citrus jambhiri
?
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
-
663275
Malus pumila
?
-
-
-
?
additional information
enzyme regulation, overview
663275
Homo sapiens
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Oncorhynchus mykiss
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Oryzias latipes
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Pimephales promelas
?
-
-
-
-
additional information
enzyme regulation, overview
663275
Stenotomus chrysops
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Vicia sativa
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Triticum aestivum
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Spinacia oleracea
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Zea mays
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Nicotiana tabacum
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Glycine max
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Arabidopsis thaliana
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Brassica napus
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Ricinus communis
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Apium graveolens
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Oryza sativa
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Ananas comosus
?
-
-
-
-
additional information
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Euphorbia lagascae
?
-
-
-
-
additional information
synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Malus pumila
?
-
-
-
-
additional information
the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Citrus jambhiri
?
-
-
-
-
additional information
the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
663275
Solanum tuberosum
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Cavia porcellus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Rattus norvegicus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Sus scrofa
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Oryctolagus cuniculus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Mesocricetus auratus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Equus caballus
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
663275
Macaca mulatta
?
-
-
-
-
additional information
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview
663275
Papio sp.
?
-
-
-
-
additional information
the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview
663275
Mus musculus
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Vicia sativa
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Triticum aestivum
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Spinacia oleracea
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Zea mays
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Solanum tuberosum
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Nicotiana tabacum
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Glycine max
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Arabidopsis thaliana
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Brassica napus
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Ricinus communis
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Apium graveolens
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Oryza sativa
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Ananas comosus
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Euphorbia lagascae
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Citrus jambhiri
?
-
-
-
-
additional information
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
663275
Malus pumila
?
-
-
-
-
additional information
substrate specificity, the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, except for the isozyme EPXH2B, overview
663275
Mus musculus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Cavia porcellus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Sus scrofa
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Oryctolagus cuniculus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Mesocricetus auratus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Equus caballus
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Macaca mulatta
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
663275
Papio sp.
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview
663275
Homo sapiens
?
-
-
-
-
additional information
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview
663275
Rattus norvegicus
?
-
-
-
-
squalene diepoxide + H2O
-
663275
Mus musculus
?
-
-
-
?
squalene-2,3-epoxide + H2O
-
663275
Mus musculus
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 62000, about
Cavia porcellus
dimer
2 * 62000, about
Equus caballus
dimer
2 * 62000, about
Homo sapiens
dimer
2 * 62000, about
Macaca mulatta
dimer
2 * 62000, about
Mesocricetus auratus
dimer
2 * 62000, about
Mus musculus
dimer
2 * 62000, about
Oryctolagus cuniculus
dimer
2 * 62000, about
Papio sp.
dimer
2 * 62000, about
Rattus norvegicus
dimer
2 * 62000, about
Sus scrofa
monomer or dimer
x * 35000, about
Ananas comosus
monomer or dimer
x * 35000, about
Apium graveolens
monomer or dimer
n * 35000, about
Arabidopsis thaliana
monomer or dimer
x * 35000, about
Brassica napus
monomer or dimer
x * 35000, about
Citrus jambhiri
monomer or dimer
x * 35000, about
Euphorbia lagascae
monomer or dimer
n * 35000, about
Glycine max
monomer or dimer
x * 35000, about
Malus pumila
monomer or dimer
x * 35000, about
Nicotiana tabacum
monomer or dimer
x * 35000, about
Oryza sativa
monomer or dimer
n * 35000, about
Ricinus communis
monomer or dimer
n * 35000, about
Solanum tuberosum
monomer or dimer
x * 35000, about
Spinacia oleracea
monomer or dimer
x * 35000, about
Triticum aestivum
monomer or dimer
x * 35000, about
Vicia sativa
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Cavia porcellus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Equus caballus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Homo sapiens
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Macaca mulatta
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Mesocricetus auratus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Mus musculus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Oryctolagus cuniculus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Papio sp.
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Rattus norvegicus
More
the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
Sus scrofa
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Cavia porcellus
-
6
5
Equus caballus
-
6
5
Macaca mulatta
-
6
5
Mesocricetus auratus
-
6
5
Oryctolagus cuniculus
-
6
5
Rattus norvegicus
-
6
5
Sus scrofa
-
6
5
Other publictions for EC 3.3.2.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747954
de Oliveira
Epoxide hydrolase of Trichode ...
Trichoderma reesei, Trichoderma reesei QM9414
Int. J. Biol. Macromol.
89
569-574
2016
-
-
1
-
-
-
-
2
-
-
1
-
-
3
-
-
1
-
-
-
-
-
4
-
1
-
3
2
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
1
-
-
-
-
4
-
1
-
3
2
1
1
-
-
-
-
-
-
2
2
731463
Shihadih
Identification of potent inhib ...
Gallus gallus
Bioorg. Med. Chem. Lett.
25
276-279
2015
-
-
-
-
-
-
7
1
1
-
-
1
-
4
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731562
Hung
Soluble epoxide hydrolase acti ...
Mus musculus
Brain Behav. Immun.
43
118-129
2015
-
-
-
-
-
-
2
-
1
-
-
-
-
5
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
731104
Sun
Soluble epoxide hydrolase-depe ...
Mus musculus
Am. J. Physiol. Heart Circ. Physiol.
306
H1146-H1153
2014
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
1
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731352
Purba
Isolation and characterization ...
Xenopus laevis
Biochim. Biophys. Acta
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2014
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1
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1
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2
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1
1
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1
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9
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4
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1
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1
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731448
Burmistrov
Symmetric adamantyl-diureas as ...
Homo sapiens
Bioorg. Med. Chem. Lett.
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20
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1
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731473
Kim
Structure-activity relationshi ...
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33
33
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1
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1
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731476
Amano
Structural insights into bindi ...
Homo sapiens
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1
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10
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1
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10
13
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1
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1
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732196
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Insight into the binding modes ...
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732298
Morisseau
Effect of soluble epoxide hydr ...
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Optimized inhibitors of solubl ...
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5
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Upregulation of soluble epoxid ...
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2013
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731441
Thalji
Discovery of 1-(1,3,5-triazin- ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
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731442
Pecic
Synthesis and structure-activi ...
Homo sapiens
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731877
Harris
Soluble epoxide hydrolase: gen ...
Homo sapiens
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2
1
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732124
Nelson
Soluble epoxide hydrolase dime ...
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1
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732722
Zhang
Role of endothelial soluble ep ...
Homo sapiens
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731230
Gupta
Soluble epoxide hydrolase: sex ...
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731291
Lonsdale
Determinants of reactivity and ...
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732283
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Development and characterizati ...
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2
1
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732301
la Buscato
Design and synthesis of dual m ...
Homo sapiens
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17
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17
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1
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732695
Lee
Soluble epoxide hydrolase acti ...
Mus musculus
PLoS ONE
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2012
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1
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732817
Froemel
Soluble epoxide hydrolase regu ...
Danio rerio
Proc. Natl. Acad. Sci. USA
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2012
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Soluble epoxide hydrolase inhi ...
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Soluble epoxide hydrolase in t ...
Rattus norvegicus
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Mammalian soluble epoxide hydr ...
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715853
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Discovery of potent inhibitors ...
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Alleviation of lung injury by ...
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-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707455
Liu
Inhibition of soluble epoxide ...
Mus musculus
Biochem. Pharmacol.
79
880-887
2010
-
-
-
-
1
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707711
Eldrup
Optimization of piperidyl-urea ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
20
571-575
2010
-
-
-
-
-
-
50
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
46
-
-
-
-
-
-
-
46
50
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707912
Mavrommatis
Intervention with fish oil, bu ...
Mus musculus
Br. J. Nutr.
103
16-24
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708017
Keserue
Hypoxia-induced pulmonary hype ...
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Cardiovasc. Res.
85
232-240
2010
-
-
1
-
-
-
7
-
2
-
-
3
-
7
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
-
2
-
-
3
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
708238
Wang
Soluble epoxide hydrolase in a ...
Homo sapiens, Mus musculus, Rattus norvegicus
Curr. Atheroscler. Rep.
12
174-183
2010
-
-
1
-
5
-
6
-
3
-
-
3
-
5
-
-
-
-
-
9
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
6
-
-
3
-
-
3
-
-
-
-
-
9
-
-
6
-
-
-
-
-
-
-
-
-
-
5
5
-
-
-
708253
Revermann
Pharmacological inhibition of ...
Mammalia
Curr. Opin. Pharmacol.
10
173-178
2010
-
-
-
-
-
-
1
-
1
-
1
-
-
3
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
708395
Tsai
Pharmacokinetic screening of s ...
Canis lupus familiaris, Homo sapiens
Eur. J. Pharm. Sci.
40
222-238
2010
-
-
-
-
-
-
30
-
2
-
-
2
-
5
-
-
-
-
-
1
-
-
6
-
2
-
-
-
2
-
-
-
-
-
14
-
-
-
-
-
-
-
14
30
-
-
2
-
-
2
-
-
-
-
-
1
-
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
709214
Chaudhary
Inhibition of soluble epoxide ...
Mus musculus, Mus musculus C57BL6
J. Cardiovasc. Pharmacol.
55
67-73
2010
-
-
-
-
-
-
1
-
-
-
-
4
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709564
Deng
Cytochrome P450 epoxygenases, ...
Homo sapiens, Mus musculus
J. Mol. Cell. Cardiol.
48
331-341
2010
-
-
-
-
1
-
1
-
2
-
-
10
-
3
-
-
-
-
-
11
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
10
-
-
-
-
-
11
-
-
10
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
709683
Luo
Inhibition or deletion of solu ...
Mus musculus, Mus musculus C57/BL6J
J. Pharmacol. Exp. Ther.
334
430-438
2010
-
-
1
-
1
-
1
-
1
-
-
-
-
3
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
709899
Xie
Development of a high throughp ...
Homo sapiens
Mol. Biotechnol.
45
207-217
2010
-
-
1
-
-
-
5
-
1
-
-
4
-
2
-
-
-
-
-
2
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
-
1
-
-
4
-
-
-
-
-
2
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710480
Nishi
Expression of the human solubl ...
Homo sapiens
Protein Expr. Purif.
69
34-38
2010
-
-
1
-
-
-
7
-
1
-
-
-
-
3
-
-
1
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
11
-
-
1
-
-
-
-
11
7
-
-
1
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710821
Nayeem
Modulation by salt intake of t ...
Mus musculus
Am. J. Physiol. Regul. Integr. Comp. Physiol.
299
R325-R333
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714311
Zhang
DNA methylation of the promote ...
Homo sapiens
Biochim. Biophys. Acta
1799
659-667
2010
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
716401
De Taeye
Expression and regulation of s ...
Mus musculus
Obesity (Silver Spring)
18
489-498
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
695933
Decker
Mammalian epoxide hydrolases i ...
Homo sapiens, Mus musculus
Arch. Toxicol.
83
297-318
2009
-
2
-
-
4
-
-
-
4
-
-
-
-
3
-
-
-
-
-
14
-
-
14
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
4
-
-
-
-
-
4
-
-
-
-
-
-
-
-
14
-
-
14
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696657
Anandan
Non-urea functionality as the ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
1066-1070
2009
-
-
-
-
-
-
28
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28
-
-
-
-
-
-
-
28
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696673
Xie
Discovery of potent non-urea i ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
2354-2359
2009
-
1
-
-
-
-
78
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
41
-
1
-
-
-
-
-
41
78
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697032
Liu
Pharmacokinetic optimization o ...
Homo sapiens, Mus musculus, Rattus norvegicus
Br. J. Pharmacol.
156
284-296
2009
-
-
-
-
-
-
21
-
-
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-
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6
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-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
18
21
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697165
Parrish
Attenuation of cisplatin nephr ...
Mus musculus
Cell Biol. Toxicol.
25
217-225
2009
-
1
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697435
Olearczyk
Administration of a substitute ...
Rattus norvegicus
Clin. Sci.
116
61-70
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697521
Gross
Soluble epoxide hydrolase: a n ...
Mus musculus, Rattus norvegicus
Curr. Opin. Investig. Drugs
10
253-258
2009
-
2
-
-
-
-
6
-
-
-
-
-
-
8
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699318
Revermann
Inhibition of the soluble epox ...
Rattus norvegicus
J. Hypertens.
27
322-331
2009
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699685
Rawal
Differential subcellular distr ...
Rattus norvegicus
J. Neurosci. Res.
87
218-227
2009
-
-
-
-
-
-
-
-
4
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1
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-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701008
Ai
Soluble epoxide hydrolase play ...
Mus musculus, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
106
564-569
2009
2
2
-
-
-
-
2
-
-
-
-
-
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7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707059
Luria
Alteration in plasma testoster ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
297
E375-E383
2009
-
-
1
-
1
-
1
-
2
-
-
1
-
3
-
-
-
-
-
6
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
6
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
707076
Manhiani
Soluble epoxide hydrolase gene ...
Mus musculus
Am. J. Physiol. Renal Physiol.
297
F740-F748
2009
-
-
-
-
1
-
1
-
1
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707303
Zhang
Inhibition of soluble epoxide ...
Mus musculus
Arterioscler. Thromb. Vasc. Biol.
29
1265-1270
2009
-
-
-
-
-
-
2
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707633
Oguro
Contribution of hydrolase and ...
Homo sapiens
Biol. Pharm. Bull.
32
1962-1967
2009
-
-
-
-
3
-
-
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1
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5
-
3
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-
2
-
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6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
5
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707669
Shen
Discovery of spirocyclic secon ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem. Lett.
19
3398-3404
2009
-
-
-
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38
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3
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-
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-
-
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42
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-
-
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-
42
38
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-
-
-
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A strategy of employing aminoh ...
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46
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46
48
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707875
Kullmann
Variation in the human soluble ...
Homo sapiens
BMC Cardiovasc. Disord.
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1
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1
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1
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1
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47
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11
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10
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Soluble epoxide hydrolase is a ...
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Gerry Brooks and epoxide hydro ...
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Zhang
Genetic variation in cytochrom ...
Homo sapiens
Pharmacogenet. Genomics
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1
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Shi
Inhibition of soluble epoxide ...
Homo sapiens
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1
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2
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1
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700966
Inceoglu
Soluble epoxide hydrolase and ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
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701243
Gschwendtner
Genetic variation in soluble e ...
Homo sapiens
Stroke
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1
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1
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701344
Lee
Genetic variations in soluble ...
Homo sapiens
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683095
Labitzke
Mitochondrial P450-dependent a ...
Gallus gallus
Arch. Biochem. Biophys.
468
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2007
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1
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2
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683229
Kim
Design of bioavailable derivat ...
Homo sapiens
Bioorg. Med. Chem.
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2007
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12
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12
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12
12
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-
-
-
-
-
-
-
-
-
-
-
-
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683503
Chiappe
Effect of ionic liquids on epo ...
Mus musculus
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2007
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1
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1
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3
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683760
Hwang
Orally bioavailable potent sol ...
Canis lupus, Felis catus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
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2007
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40
40
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1
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683761
Kim
1,3-disubstituted ureas functi ...
Homo sapiens
J. Med. Chem.
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5217-5226
2007
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8
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8
8
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684014
Ai
Angiotensin II up-regulates so ...
Bos taurus, Homo sapiens, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
104
9018-9023
2007
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4
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660928
Enayetallah
Effects of human soluble epoxi ...
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Biochem. Biophys. Res. Commun.
341
254-260
2006
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1
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1
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1
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1
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662565
Enayetallah
Cell-specific subcellular loca ...
Homo sapiens
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2006
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663193
Harris
The cloning and characterizati ...
Gallus gallus
Poult. Sci.
85
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2006
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1
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5
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1
1
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1
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1
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5
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1
1
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1
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1
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1
4
3
5
1
1
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1
1
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1
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663350
Gomez
Human soluble epoxide hydrolas ...
Homo sapiens
Protein Sci.
15
58-64
2006
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1
1
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12
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1
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1
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1
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1
1
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1
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12
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1
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1
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1
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-
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681501
Enayetallah
Distribution of soluble epoxid ...
Homo sapiens
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37
133-141
2006
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1
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11
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1
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-
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-
-
-
-
-
-
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11
-
-
-
-
-
-
-
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683063
Wolf
Development of a high-throughp ...
Homo sapiens
Anal. Biochem.
355
71-80
2006
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1
1
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5
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-
1
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1
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1
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-
-
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5
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1
1
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-
-
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5
5
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-
-
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-
-
-
-
-
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1
-
1
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1
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683240
Jones
Synthesis and SAR of conformat ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
5212-5216
2006
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1
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14
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14
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1
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1
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14
14
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683355
Seubert
Role of soluble epoxide hydrol ...
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Circ. Res.
99
442-450
2006
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1
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1
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-
1
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1
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-
-
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-
-
-
-
-
-
-
1
-
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-
-
-
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-
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683815
Hopmann
Insights into the reaction mec ...
Homo sapiens
J. Phys. Chem. B
110
21299-21310
2006
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3
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-
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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-
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660686
Shin
Identification and characteriz ...
Mus musculus
Amino Acids
28
63-69
2005
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-
-
-
-
-
-
-
1
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1
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2
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2
1
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3
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1
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-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
1
-
3
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
660702
Jones
Fluorescent substrates for sol ...
Homo sapiens, Mus musculus
Anal. Biochem.
343
66-75
2005
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2
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-
-
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12
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2
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16
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22
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2
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2
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-
-
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2
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-
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12
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2
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-
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16
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22
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2
-
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2
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660713
Morisseau
Epoxide hydrolases: mechanisms ...
Homo sapiens, Mus musculus, Rattus norvegicus
Annu. Rev. Pharmacol. Toxicol.
45
311-333
2005
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3
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1
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3
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9
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10
4
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1
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1
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4
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2
3
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23
1
3
3
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1
3
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9
-
-
10
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
661168
Tran
Lipid sulfates and sulfonates ...
Homo sapiens
Biochemistry
44
12179-12187
2005
-
-
-
-
-
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30
-
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1
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-
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1
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-
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2
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1
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1
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29
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-
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29
30
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
661683
Sellers
Novel mechanism of brain solub ...
Rattus norvegicus
FASEB J.
19
626-628
2005
-
-
-
-
-
-
2
-
1
-
-
2
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3
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663254
Schmelzer
Soluble epoxide hydrolase is a ...
Mus musculus
Proc. Natl. Acad. Sci. USA
102
9772-9777
2005
-
1
-
-
-
-
2
-
1
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
663275
Newman
Epoxide hydrolases: their role ...
Ananas comosus, Apium graveolens, Arabidopsis thaliana, Brassica napus, Cavia porcellus, Citrus jambhiri, Equus caballus, Euphorbia lagascae, Glycine max, Homo sapiens, Macaca mulatta, Malus pumila, Mesocricetus auratus, Mus musculus, Nicotiana tabacum, Oncorhynchus mykiss, Oryctolagus cuniculus, Oryza sativa, Oryzias latipes, Papio sp., Pimephales promelas, Rattus norvegicus, Ricinus communis, Solanum tuberosum, Spinacia oleracea, Stenotomus chrysops, Sus scrofa, Triticum aestivum, Vicia sativa, Zea mays
Prog. Lipid Res.
44
1-51
2005
25
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3
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33
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25
33
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32
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2
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72
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134
35
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7
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25
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3
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33
-
25
33
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2
-
72
-
-
134
35
-
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7
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-
654749
Gomez
Structure of human epoxide hyd ...
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Biochemistry
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2004
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656889
Reetz
Enhancing the enantioselectivi ...
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Org. Lett.
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2004
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1
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657384
Monfort
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Enzymatic transformations. Par ...
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60
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2004
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1
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657394
DuTeaux
Epoxide hydrolases in the rat ...
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Toxicol. Sci.
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2004
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3
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6
1
1
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1
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660664
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Vascular localization of solub ...
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Am. J. Physiol.
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2004
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2
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3
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660799
Srivastava
Polymorphisms in human soluble ...
Homo sapiens
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2004
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1
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7
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1
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7
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1
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1
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655100
Li
Epoxide hydrolase-catalyzed re ...
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2003
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1
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2
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1
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1
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657132
Edqvist
A germination-specific epoxide ...
Euphorbia lagascae
Planta
216
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2003
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1
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657156
Newman
The soluble epoxide hydrolase ...
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Proc. Natl. Acad. Sci. USA
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2003
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8
1
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1
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24
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1
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8
1
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662594
McElroy
QSAR and classification of mur ...
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2003
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2
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2
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663199
Cronin
The N-terminal domain of mamma ...
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2003
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6
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3
6
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1
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678899
Gong
Improved catalytic performance ...
Bacillus megaterium, Bacillus megaterium ECU1001
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2003
1
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9
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2
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3
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1
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1
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654503
Summerer
Stereochemical features of the ...
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2002
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3
-
1
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655444
Bellevik
Brassica napus soluble epoxide ...
Brassica napus
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2002
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8
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1
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2
1
1
1
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1
1
1
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657255
Bellevik
Overexpression of Arabidopsis ...
Arabidopsis thaliana
Protein Expr. Purif.
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2002
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1
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1
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2
1
1
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1
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1
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661922
Schiott
Reaction mechanism of soluble ...
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2002
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1
1
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656558
Nardini
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Structure and mechanism of the ...
Agrobacterium tumefaciens, Agrobacterium tumefaciens AD1
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1035-1042
2001
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Morisseau
Cress and potato soluble epoxi ...
Arabidopsis thaliana, cress, Homo sapiens, Mus musculus, Rattus norvegicus, Solanum tuberosum
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321-332
2000
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654576
Rink
Tyrosine residues serve as pro ...
Agrobacterium tumefaciens, Agrobacterium tumefaciens AD1
Biochemistry
39
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2000
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13
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8
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1
5
1
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1
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657379
Zou
Structure of Aspergillus niger ...
Aspergillus niger, Aspergillus niger LCP521
Structure Fold. Des.
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111-122
2000
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1
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661496
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Soluble epoxide hydrolase regu ...
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2
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1
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5
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Arahira
Purification, molecular clonin ...
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Cloning and molecular characte ...
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Inhibition of soluble and micr ...
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661476
Lacourciere
Microsomal ans soluble epoxide ...
Rattus norvegicus
Chem. Res. Toxicol.
7
121-124
1994
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
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1
-
-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663099
Stapleton
Cloning and expression of solu ...
no activity in Trichoplusia ni, Solanum tuberosum
Plant J.
6
251-258
1994
1
-
1
-
-
-
3
-
1
-
1
-
-
3
-
-
-
-
-
1
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
-
-
1
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661511
Dietze
Inhibition of human and murine ...
Homo sapiens, Mus musculus
Comp. Biochem. Physiol. B
104
299-308
1993
-
-
-
-
-
-
34
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4
-
-
-
-
5
-
-
2
-
-
2
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34
-
-
4
-
-
-
-
-
-
2
-
2
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
661890
Dietze
The interaction of cytosolic e ...
Mus musculus
Int. J. Biochem.
25
43-52
1993
1
-
-
-
-
-
13
5
1
-
-
-
-
1
-
-
1
-
-
1
-
-
4
-
2
-
-
4
1
-
-
-
-
-
18
1
-
-
-
-
-
-
18
13
-
5
1
-
-
-
-
-
-
1
-
1
-
-
4
-
2
-
-
4
1
-
-
-
-
-
-
-
-
-
208923
Blee
Occurence of fatty acid epoxid ...
Glycine max
Biochem. J.
282
711-714
1992
-
-
-
-
-
-
4
2
1
-
2
-
-
1
-
-
1
-
-
1
-
-
2
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
1
-
2
-
-
-
-
1
-
1
-
-
2
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
208929
Halarnkar
Formation of cyclic products f ...
Mus musculus
Arch. Biochem. Biophys.
294
586-593
1992
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208930
Nourooz-Zadeh
Biochemical characterization o ...
Mus musculus, Mus musculus ENU4
Comp. Biochem. Physiol. C
103
207-214
1992
-
-
-
-
-
-
-
-
1
-
-
2
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208928
Chang
Purification and characterizat ...
Mus musculus
Arch. Biochem. Biophys.
285
276-284
1991
-
-
-
-
-
-
13
4
2
-
2
-
-
2
-
-
1
-
-
2
1
-
2
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
-
4
2
-
2
-
-
-
-
1
-
2
1
-
2
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
661024
Dietze
Inhibition of cytosolic epoxid ...
Mus musculus
Biochem. Pharmacol.
42
1163-1175
1991
1
-
-
-
-
-
22
-
2
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
17
1
-
-
-
-
-
-
17
22
-
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
208931
Dietze
Human and murine cytosolic epo ...
Homo sapiens, Mus musculus
Int. J. Biochem.
22
461-470
1990
-
-
-
-
-
-
-
-
4
-
3
-
-
5
-
-
-
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
3
-
-
-
-
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208934
Thomas
Rat and human liver cytosolic ...
Homo sapiens, Rattus norvegicus
Environ. Health Perspect.
88
49-55
1990
3
-
1
-
-
-
6
1
3
-
5
-
-
8
-
-
2
-
-
3
-
-
6
3
-
-
-
-
4
-
-
-
-
-
-
3
-
1
-
-
-
-
-
6
-
1
3
-
5
-
-
-
-
2
-
3
-
-
6
3
-
-
-
-
4
-
-
-
-
-
-
-
-
-
208918
Miki
Enzymic conversion of 11,12-le ...
Cavia porcellus
J. Biol. Chem.
264
5799-5805
1989
-
-
-
-
-
-
1
1
4
-
1
-
-
4
-
-
1
-
-
7
-
-
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
4
-
1
-
-
-
-
1
-
7
-
-
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208913
Meijer
Cytosolic epoxide hydrolase ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Chem. Biol. Interact.
64
207-249
1988
-
-
-
-
-
-
2
-
-
-
5
3
-
11
-
-
2
-
-
2
-
-
33
6
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
5
3
-
-
-
2
-
2
-
-
33
6
-
-
3
-
-
-
-
-
-
-
-
-
-
-
208914
Wixtrom
Affinity purification of cytos ...
Mus musculus
Anal. Biochem.
169
71-80
1988
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208916
Schladt
Purification and characterizat ...
Rattus norvegicus
Eur. J. Biochem.
176
31-37
1988
-
-
-
-
-
-
7
1
2
-
2
-
-
7
-
-
1
-
-
2
1
-
3
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
2
-
2
-
-
-
-
1
-
2
1
-
3
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
208917
Schladt
Human liver cytosolic epoxide ...
Homo sapiens
Eur. J. Biochem.
176
715-723
1988
-
-
-
-
-
-
2
9
2
-
-
-
-
3
-
-
1
-
-
1
1
-
7
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
9
2
-
-
-
-
-
-
1
-
1
1
-
7
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
208910
Hammock
Comparison of crude and affini ...
Mus musculus
Arch. Biochem. Biophys.
244
292-309
1986
1
-
-
-
-
-
5
-
1
-
2
-
-
4
-
-
1
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
5
-
-
1
-
2
-
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662085
Haeggstroem
Leukotriene A4. Enzymatic conv ...
Mus musculus
J. Biol. Chem.
261
6332-6337
1986
1
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
1
-
-
2
-
-
2
-
1
-
1
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
2
-
-
2
-
1
-
1
-
2
-
-
-
-
-
-
-
-
-
208877
Wixtrom
-
Membrane-bound and soluble-fra ...
Homo sapiens, Macaca mulatta, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Biochem. Pharmacol. Toxicol.
1
1-93
1985
125
-
-
-
-
-
30
-
30
-
-
-
-
5
-
-
1
-
-
15
5
-
80
-
-
-
-
-
-
-
-
-
-
-
-
125
-
-
-
-
-
-
-
30
-
-
30
-
-
-
-
-
-
1
-
15
5
-
80
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208904
Meijer
Properties of cytosolic epoxid ...
Mus musculus
Eur. J. Biochem.
148
421-430
1985
-
-
-
-
-
-
-
-
2
-
2
-
-
4
-
-
1
-
-
2
2
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
1
-
2
2
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208905
Prestwich
Rapid purification of cytosoli ...
Mus musculus
Proc. Natl. Acad. Sci. USA
82
1663-1667
1985
-
-
-
-
-
-
2
-
3
-
2
-
-
3
-
-
-
-
-
3
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
2
-
-
-
-
-
-
3
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208906
Meijer
Properties of cytosolic epoxid ...
Mus musculus
Eur. J. Biochem.
150
7-16
1985
6
-
-
-
-
-
12
6
2
-
-
-
-
3
1
-
-
-
-
2
-
1
6
-
1
1
-
-
1
1
-
-
-
-
-
6
-
-
-
-
-
-
-
12
-
6
2
-
-
-
-
1
-
-
-
2
-
1
6
-
1
1
-
-
1
1
-
-
-
-
-
-
-
-
208902
Gill
Purification of mouse liver cy ...
Mus musculus
Biochem. Biophys. Res. Commun.
112
763-769
1983
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
-
1
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
1
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
208898
Waechter
Purification and characterizat ...
Oryctolagus cuniculus
Eur. J. Biochem.
125
457-461
1982
-
-
-
-
-
-
-
1
2
-
2
-
-
2
-
-
1
-
-
2
1
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
208900
Wang
Purification of human liver cy ...
Homo sapiens, Rattus norvegicus
Biochemistry
21
5769-5776
1982
-
-
-
-
-
-
-
-
3
-
3
-
-
3
-
-
1
-
-
3
4
-
14
4
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
1
-
3
4
-
14
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
208896
Ota
Cytosolic and microsomal epoxi ...
Cavia porcellus, Mus musculus, Rattus norvegicus
Science
207
1479-1481
1980
-
-
-
-
-
-
-
-
3
-
-
-
-
6
-
-
-
-
-
6
6
-
6
-
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
6
6
-
6
-
-
-
-
-
3
3
-
-
-
-
-
-
-
-