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Literature summary for 3.3.2.10 extracted from
- Cell-specific subcellular localization of soluble epoxide hydrolase in human tissues (2006), J. Histochem. Cytochem., 54, 329-335.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | sEH may have tissue- or cell-type-specific functionality | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| additional information | tissue-specific subcellular localization analysis | Homo sapiens | - |
- |
| additional information | human sEH subcellular localization is tissue dependent, not detectable in mitochondria or nucleus | Homo sapiens | - |
- |
| peroxisome | - |
Homo sapiens | 5777 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an epoxide + H2O = a glycol | the C-terminal part harbors the epoxide hydrolase activity, the phosphatase activity of the enzyme is located at the N-terminal part of EC 3.1.3.76, both catalytic sites act independently | Homo sapiens |
aSource Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | cytosolic localization | Homo sapiens | - |
| adrenal gland | exclusively cytosolic | Homo sapiens | - |
| alveolar wall | cytosolic localization | Homo sapiens | - |
| alveolar wall | exclusively cytosolic | Homo sapiens | - |
| anterior pituitary gland | cytosolic localization | Homo sapiens | - |
| blood vessel | cytosolic localization | Homo sapiens | - |
| blood vessel | exclusively cytosolic | Homo sapiens | - |
| ejaculatory duct epithelium | cytosolic localization | Homo sapiens | - |
| endometrium | cytosolic localization | Homo sapiens | - |
| hepatocyte | cytosolic and peroxisomal localization | Homo sapiens | - |
| hepatocyte | cytosolic and peroxisomal | Homo sapiens | - |
| intestinal epithelium | cytosolic localization | Homo sapiens | - |
| intestinal epithelium | exclusively cytosolic | Homo sapiens | - |
| lung | exclusively cytosolic | Homo sapiens | - |
| lymphoid follicle | cytosolic localization | Homo sapiens | - |
| lymphoid follicle | exclusively cytosolic | Homo sapiens | - |
| additional information | in anterior pituitary cells exclusively cytosolic | Homo sapiens | - |
| pancreatic islet | cytosolic localization | Homo sapiens | - |
| pancreatic islet | exclusively cytosolic | Homo sapiens | - |
| prostate epithelium | exclusively cytosolic | Homo sapiens | - |
| proximal tubule | renal proximal tubule, cytosolic and peroxisomal | Homo sapiens | - |
| renal proximal tubule | cytosolic and peroxisomal localization | Homo sapiens | - |
| uterine endometrium | exclusively cytosolic | Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the C-terminal part, with a hydrolase alpha/beta-fold, harbors the epoxide hydrolase activity, the enzyme's phosphatase activity of EC3.1.3.76 is located at the N-terminal part which has a different alpha/beta-fold | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | see also EC 3.1.3.76 | Homo sapiens |
| SEH | - |
Homo sapiens |
| soluble epoxide hydrolase | - |
Homo sapiens |
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