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Literature summary for 3.3.2.10 extracted from

  • Wixtrom, R.N.; Hammock, B.D.
    Membrane-bound and soluble-fraction epoxide hydrolases (1985), Biochem. Pharmacol. Toxicol., 1, 1-93.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
1-(2-cyanophenyl)-imidazole
-
Mus musculus
1-(2-cyanophenyl)-imidazole
-
Homo sapiens
1-(2-cyanophenyl)-imidazole
-
Rattus norvegicus
1-(2-cyanophenyl)-imidazole
-
Oryctolagus cuniculus
1-(2-cyanophenyl)-imidazole
-
Macaca mulatta
1-(2-Isopropylphenyl)-imidazole
-
Mus musculus
1-(2-Isopropylphenyl)-imidazole
-
Homo sapiens
1-(2-Isopropylphenyl)-imidazole
-
Rattus norvegicus
1-(2-Isopropylphenyl)-imidazole
-
Oryctolagus cuniculus
1-(2-Isopropylphenyl)-imidazole
-
Macaca mulatta
4-azafluorene
-
Mus musculus
4-azafluorene
-
Homo sapiens
4-azafluorene
-
Rattus norvegicus
4-azafluorene
-
Oryctolagus cuniculus
4-azafluorene
-
Macaca mulatta
4-phenylpyridine
-
Mus musculus
4-phenylpyridine
-
Homo sapiens
4-phenylpyridine
-
Rattus norvegicus
4-phenylpyridine
-
Oryctolagus cuniculus
4-phenylpyridine
-
Macaca mulatta
5,6-benzoflavone
-
Mus musculus
5,6-benzoflavone
-
Homo sapiens
5,6-benzoflavone
-
Rattus norvegicus
5,6-benzoflavone
-
Oryctolagus cuniculus
5,6-benzoflavone
-
Macaca mulatta
7,8-Benzoflavone
-
Mus musculus
7,8-Benzoflavone
-
Homo sapiens
7,8-Benzoflavone
-
Rattus norvegicus
7,8-Benzoflavone
-
Oryctolagus cuniculus
7,8-Benzoflavone
-
Macaca mulatta
9-fluorenone
-
Mus musculus
9-fluorenone
-
Homo sapiens
9-fluorenone
-
Rattus norvegicus
9-fluorenone
-
Oryctolagus cuniculus
9-fluorenone
-
Macaca mulatta
benzil
-
Mus musculus
benzil
-
Homo sapiens
benzil
-
Rattus norvegicus
benzil
-
Oryctolagus cuniculus
benzil
-
Macaca mulatta
benzophenone
-
Mus musculus
benzophenone
-
Homo sapiens
benzophenone
-
Rattus norvegicus
benzophenone
-
Oryctolagus cuniculus
benzophenone
-
Macaca mulatta
benzyl phenyl ketone
-
Mus musculus
benzyl phenyl ketone
-
Homo sapiens
benzyl phenyl ketone
-
Rattus norvegicus
benzyl phenyl ketone
-
Oryctolagus cuniculus
benzyl phenyl ketone
-
Macaca mulatta
chalcone
-
Mus musculus
chalcone
-
Homo sapiens
chalcone
-
Rattus norvegicus
chalcone
-
Oryctolagus cuniculus
chalcone
-
Macaca mulatta
Chalcone oxide
-
Mus musculus
Chalcone oxide
-
Homo sapiens
Chalcone oxide
-
Rattus norvegicus
Chalcone oxide
-
Oryctolagus cuniculus
Chalcone oxide
-
Macaca mulatta
cyclobenzaprine
-
Mus musculus
cyclobenzaprine
-
Homo sapiens
cyclobenzaprine
-
Rattus norvegicus
cyclobenzaprine
-
Oryctolagus cuniculus
cyclobenzaprine
-
Macaca mulatta
cyclobenzaprine 9,10-epoxide
-
Mus musculus
cyclobenzaprine 9,10-epoxide
-
Homo sapiens
cyclobenzaprine 9,10-epoxide
-
Rattus norvegicus
cyclobenzaprine 9,10-epoxide
-
Oryctolagus cuniculus
cyclobenzaprine 9,10-epoxide
-
Macaca mulatta
diphenylcyclopropenone
-
Mus musculus
diphenylcyclopropenone
-
Homo sapiens
diphenylcyclopropenone
-
Rattus norvegicus
diphenylcyclopropenone
-
Oryctolagus cuniculus
diphenylcyclopropenone
-
Macaca mulatta
ellipticine
-
Mus musculus
ellipticine
-
Homo sapiens
ellipticine
-
Rattus norvegicus
ellipticine
-
Oryctolagus cuniculus
ellipticine
-
Macaca mulatta
ethanol
-
Mus musculus
ethanol
-
Homo sapiens
ethanol
-
Rattus norvegicus
ethanol
-
Oryctolagus cuniculus
ethanol
-
Macaca mulatta
flavone
-
Mus musculus
flavone
-
Homo sapiens
flavone
-
Rattus norvegicus
flavone
-
Oryctolagus cuniculus
flavone
-
Macaca mulatta
harman
-
Mus musculus
harman
-
Homo sapiens
harman
-
Rattus norvegicus
harman
-
Oryctolagus cuniculus
harman
-
Macaca mulatta
Isoquinoline
-
Mus musculus
Isoquinoline
-
Homo sapiens
Isoquinoline
-
Rattus norvegicus
Isoquinoline
-
Oryctolagus cuniculus
Isoquinoline
-
Macaca mulatta
Metyrapone
-
Mus musculus
Metyrapone
-
Homo sapiens
Metyrapone
-
Rattus norvegicus
Metyrapone
-
Oryctolagus cuniculus
Metyrapone
-
Macaca mulatta
additional information the enzyme is induced by several substances, e.g. 2-acetylfluorene, alpha-1-acetylmethadol, butylated hydroxyanisole, butylated hydroxytoluene, chalcone, gamma-chlordane, 1,2-dibromo-3-chloropropane, ethoxyquin, isosafrole, 3-methylcholanthrene, alpha-naphthoflavone, phenobarbital, polychlorinated and/or polybrominated biphenyls, pregnenolone-16alpha-carbonitrile, and trans-stilbene oxide Mus musculus
additional information the enzyme is induced by several substances, e.g. 2-acetylfluorene, alpha-1-acetylmethadol, butylated hydroxyanisole, butylated hydroxytoluene, chalcone, gamma-chlordane, 1,2-dibromo-3-chloropropane, ethoxyquin, isosafrole, 3-methylcholanthrene, alpha-naphthoflavone, phenobarbital, polychlorinated and/or polybrominated biphenyls, pregnenolone-16alpha-carbonitrile, and trans-stilbene oxide Homo sapiens
additional information the enzyme is induced by several substances, e.g. 2-acetylfluorene, alpha-1-acetylmethadol, butylated hydroxyanisole, butylated hydroxytoluene, chalcone, gamma-chlordane, 1,2-dibromo-3-chloropropane, ethoxyquin, isosafrole, 3-methylcholanthrene, alpha-naphthoflavone, phenobarbital, polychlorinated and/or polybrominated biphenyls, pregnenolone-16alpha-carbonitrile, and trans-stilbene oxide Rattus norvegicus
additional information the enzyme is induced by several substances, e.g. 2-acetylfluorene, alpha-1-acetylmethadol, butylated hydroxyanisole, butylated hydroxytoluene, chalcone, gamma-chlordane, 1,2-dibromo-3-chloropropane, ethoxyquin, isosafrole, 3-methylcholanthrene, alpha-naphthoflavone, phenobarbital, polychlorinated and/or polybrominated biphenyls, pregnenolone-16alpha-carbonitrile, and trans-stilbene oxide Oryctolagus cuniculus
additional information the enzyme is induced by several substances, e.g. 2-acetylfluorene, alpha-1-acetylmethadol, butylated hydroxyanisole, butylated hydroxytoluene, chalcone, gamma-chlordane, 1,2-dibromo-3-chloropropane, ethoxyquin, isosafrole, 3-methylcholanthrene, alpha-naphthoflavone, phenobarbital, polychlorinated and/or polybrominated biphenyls, pregnenolone-16alpha-carbonitrile, and trans-stilbene oxide Macaca mulatta
norharman
-
Mus musculus
norharman
-
Homo sapiens
norharman
-
Rattus norvegicus
norharman
-
Oryctolagus cuniculus
norharman
-
Macaca mulatta
propyl phenyl ketone
-
Mus musculus
propyl phenyl ketone
-
Homo sapiens
propyl phenyl ketone
-
Rattus norvegicus
propyl phenyl ketone
-
Oryctolagus cuniculus
propyl phenyl ketone
-
Macaca mulatta
Quinoline
-
Mus musculus
Quinoline
-
Homo sapiens
Quinoline
-
Rattus norvegicus
Quinoline
-
Oryctolagus cuniculus
Quinoline
-
Macaca mulatta

Inhibitors

Inhibitors Comment Organism Structure
1,1,1-Trichloropropene 2,3-oxide
-
Homo sapiens
1,1,1-Trichloropropene 2,3-oxide
-
Macaca mulatta
1,1,1-Trichloropropene 2,3-oxide
-
Mus musculus
1,1,1-Trichloropropene 2,3-oxide
-
Oryctolagus cuniculus
1,1,1-Trichloropropene 2,3-oxide
-
Rattus norvegicus
2-Bromo-4'-nitroacetophenone
-
Homo sapiens
2-Bromo-4'-nitroacetophenone
-
Macaca mulatta
2-Bromo-4'-nitroacetophenone
-
Mus musculus
2-Bromo-4'-nitroacetophenone
-
Oryctolagus cuniculus
2-Bromo-4'-nitroacetophenone
-
Rattus norvegicus
cyclohexane 1,2-oxide
-
Homo sapiens
cyclohexane 1,2-oxide
-
Macaca mulatta
cyclohexane 1,2-oxide
-
Mus musculus
cyclohexane 1,2-oxide
-
Oryctolagus cuniculus
cyclohexane 1,2-oxide
-
Rattus norvegicus
p-Hydroxymercuriphenylsulfonate
-
Homo sapiens
p-Hydroxymercuriphenylsulfonate
-
Macaca mulatta
p-Hydroxymercuriphenylsulfonate
-
Mus musculus
p-Hydroxymercuriphenylsulfonate
-
Oryctolagus cuniculus
p-Hydroxymercuriphenylsulfonate
-
Rattus norvegicus
styrene oxide
-
Homo sapiens
styrene oxide
-
Macaca mulatta
styrene oxide
-
Mus musculus
styrene oxide
-
Oryctolagus cuniculus
styrene oxide
-
Rattus norvegicus
substituted chalcone oxides
-
Homo sapiens
substituted chalcone oxides
-
Macaca mulatta
substituted chalcone oxides
-
Mus musculus
substituted chalcone oxides
-
Oryctolagus cuniculus
substituted chalcone oxides
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum rough and smooth Mus musculus 5783
-
endoplasmic reticulum rough and smooth Homo sapiens 5783
-
endoplasmic reticulum rough and smooth Rattus norvegicus 5783
-
endoplasmic reticulum rough and smooth Oryctolagus cuniculus 5783
-
endoplasmic reticulum rough and smooth Macaca mulatta 5783
-
Golgi apparatus
-
Mus musculus 5794
-
Golgi apparatus
-
Homo sapiens 5794
-
Golgi apparatus
-
Rattus norvegicus 5794
-
Golgi apparatus
-
Oryctolagus cuniculus 5794
-
Golgi apparatus
-
Macaca mulatta 5794
-
membrane
-
Mus musculus 16020
-
membrane
-
Homo sapiens 16020
-
membrane
-
Rattus norvegicus 16020
-
membrane
-
Oryctolagus cuniculus 16020
-
membrane
-
Macaca mulatta 16020
-
additional information highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum Mus musculus
-
-
additional information highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum Homo sapiens
-
-
additional information highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum Rattus norvegicus
-
-
additional information highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum Oryctolagus cuniculus
-
-
additional information highest level found in smooth endoplasmic reticulum, lower levels observed in rough endoplasmic reticulum, Golgi apparatus, nuclear membrane and plasma membrane. The enzyme is synthesized in membrane-bound polysomes and inserted cotranslationally into the endoplasmic reticulum Macaca mulatta
-
-
nuclear membrane
-
Mus musculus 31965
-
nuclear membrane
-
Homo sapiens 31965
-
nuclear membrane
-
Rattus norvegicus 31965
-
nuclear membrane
-
Oryctolagus cuniculus 31965
-
nuclear membrane
-
Macaca mulatta 31965
-
plasma membrane
-
Mus musculus 5886
-
plasma membrane
-
Homo sapiens 5886
-
plasma membrane
-
Rattus norvegicus 5886
-
plasma membrane
-
Oryctolagus cuniculus 5886
-
plasma membrane
-
Macaca mulatta 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca mulatta
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from liver Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney high activity Mus musculus
-
kidney high activity Homo sapiens
-
kidney high activity Rattus norvegicus
-
kidney high activity Oryctolagus cuniculus
-
kidney high activity Macaca mulatta
-
liver high activity Mus musculus
-
liver high activity Homo sapiens
-
liver high activity Rattus norvegicus
-
liver high activity Oryctolagus cuniculus
-
liver high activity Macaca mulatta
-
testis high activity Mus musculus
-
testis high activity Homo sapiens
-
testis high activity Rattus norvegicus
-
testis high activity Oryctolagus cuniculus
-
testis high activity Macaca mulatta
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
several analytical and activity assay methods Mus musculus
additional information
-
several analytical and activity assay methods Homo sapiens
additional information
-
several analytical and activity assay methods Rattus norvegicus
additional information
-
several analytical and activity assay methods Oryctolagus cuniculus
additional information
-
several analytical and activity assay methods Macaca mulatta

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O i.e. HEOM Mus musculus ?
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O i.e. HEOM Homo sapiens ?
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O i.e. HEOM Rattus norvegicus ?
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O i.e. HEOM Oryctolagus cuniculus ?
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O i.e. HEOM Macaca mulatta ?
-
?
2,3-squalene oxide + H2O
-
Mus musculus ?
-
?
2,3-squalene oxide + H2O
-
Homo sapiens ?
-
?
2,3-squalene oxide + H2O
-
Rattus norvegicus ?
-
?
2,3-squalene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
2,3-squalene oxide + H2O
-
Macaca mulatta ?
-
?
2-acetylaminofluorene + H2O
-
Mus musculus ?
-
?
2-acetylaminofluorene + H2O
-
Homo sapiens ?
-
?
2-acetylaminofluorene + H2O
-
Rattus norvegicus ?
-
?
2-acetylaminofluorene + H2O
-
Oryctolagus cuniculus ?
-
?
2-acetylaminofluorene + H2O
-
Macaca mulatta ?
-
?
4-nitrostyrene oxide + H2O
-
Mus musculus ?
-
?
4-nitrostyrene oxide + H2O
-
Homo sapiens ?
-
?
4-nitrostyrene oxide + H2O
-
Rattus norvegicus ?
-
?
4-nitrostyrene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
4-nitrostyrene oxide + H2O
-
Macaca mulatta ?
-
?
arochlor 1254 + H2O
-
Mus musculus ?
-
?
arochlor 1254 + H2O
-
Homo sapiens ?
-
?
arochlor 1254 + H2O
-
Rattus norvegicus ?
-
?
arochlor 1254 + H2O
-
Oryctolagus cuniculus ?
-
?
arochlor 1254 + H2O
-
Macaca mulatta ?
-
?
benzopyrene 4,5-oxide + H2O
-
Mus musculus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Homo sapiens (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Rattus norvegicus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Oryctolagus cuniculus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Macaca mulatta (-)benzopyrene 4,5-dihydrodiol
-
?
cis-stilbene oxide + H2O
-
Mus musculus ?
-
?
cis-stilbene oxide + H2O
-
Homo sapiens ?
-
?
cis-stilbene oxide + H2O
-
Rattus norvegicus ?
-
?
cis-stilbene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
cis-stilbene oxide + H2O
-
Macaca mulatta ?
-
?
clofibrate + H2O
-
Mus musculus ?
-
?
clofibrate + H2O
-
Homo sapiens ?
-
?
clofibrate + H2O
-
Rattus norvegicus ?
-
?
clofibrate + H2O
-
Oryctolagus cuniculus ?
-
?
clofibrate + H2O
-
Macaca mulatta ?
-
?
di(2-ethylhexyl)phthalate + H2O
-
Mus musculus ?
-
?
di(2-ethylhexyl)phthalate + H2O
-
Homo sapiens ?
-
?
di(2-ethylhexyl)phthalate + H2O
-
Rattus norvegicus ?
-
?
di(2-ethylhexyl)phthalate + H2O
-
Oryctolagus cuniculus ?
-
?
di(2-ethylhexyl)phthalate + H2O
-
Macaca mulatta ?
-
?
additional information substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides Mus musculus ?
-
?
additional information substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides Homo sapiens ?
-
?
additional information substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides Rattus norvegicus ?
-
?
additional information substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides Oryctolagus cuniculus ?
-
?
additional information substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides Macaca mulatta ?
-
?
phenanthrene-9,10-oxide + H2O
-
Mus musculus ?
-
?
phenanthrene-9,10-oxide + H2O
-
Homo sapiens ?
-
?
phenanthrene-9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
phenanthrene-9,10-oxide + H2O
-
Oryctolagus cuniculus ?
-
?
phenanthrene-9,10-oxide + H2O
-
Macaca mulatta ?
-
?
phenobarbital + H2O
-
Mus musculus ?
-
?
phenobarbital + H2O
-
Homo sapiens ?
-
?
phenobarbital + H2O
-
Rattus norvegicus ?
-
?
phenobarbital + H2O
-
Oryctolagus cuniculus ?
-
?
phenobarbital + H2O
-
Macaca mulatta ?
-
?
styrene oxide + H2O
-
Mus musculus ?
-
?
styrene oxide + H2O
-
Homo sapiens ?
-
?
styrene oxide + H2O
-
Rattus norvegicus ?
-
?
styrene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
styrene oxide + H2O
-
Macaca mulatta ?
-
?
trans-9,10-epoxystearate + H2O
-
Mus musculus ?
-
?
trans-9,10-epoxystearate + H2O
-
Homo sapiens ?
-
?
trans-9,10-epoxystearate + H2O
-
Rattus norvegicus ?
-
?
trans-9,10-epoxystearate + H2O
-
Oryctolagus cuniculus ?
-
?
trans-9,10-epoxystearate + H2O
-
Macaca mulatta ?
-
?
trans-ethyl styrene oxide + H2O
-
Mus musculus ?
-
?
trans-ethyl styrene oxide + H2O
-
Homo sapiens ?
-
?
trans-ethyl styrene oxide + H2O
-
Rattus norvegicus ?
-
?
trans-ethyl styrene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
trans-ethyl styrene oxide + H2O
-
Macaca mulatta ?
-
?
trans-stilbene oxide + H2O
-
Mus musculus ?
-
?
trans-stilbene oxide + H2O
-
Homo sapiens ?
-
?
trans-stilbene oxide + H2O
-
Rattus norvegicus ?
-
?
trans-stilbene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
trans-stilbene oxide + H2O
-
Macaca mulatta ?
-
?