Application | Comment | Organism |
---|---|---|
medicine | inhibitors of methylthioadenosine/S-adenosylhomocysteine nucleosidase are anti-infective drugs against various bacterial pathogens | Escherichia coli |
medicine | inhibitors of MTA/SAH nucleosidase are anti-infective drugs against various bacterial pathogens | Borreliella burgdorferi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-deoxyadenosine + H2O | Escherichia coli | - |
5-deoxy-D-ribose + adenine | - |
? | |
5'-deoxyadenosine + H2O | Borreliella burgdorferi | - |
5-deoxy-D-ribose + adenine | - |
? | |
5'-methylthioadenosine + H2O | Escherichia coli | - |
5-methylthio-D-ribose + adenine | - |
? | |
5'-methylthioadenosine + H2O | Borreliella burgdorferi | - |
5-methylthio-D-ribose + adenine | - |
? | |
S-adenosyl-L-homocysteine + H2O | Escherichia coli | - |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
? | |
S-adenosyl-L-homocysteine + H2O | Borreliella burgdorferi | - |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Borreliella burgdorferi | - |
- |
- |
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-deoxyadenosine + H2O | - |
Escherichia coli | 5-deoxy-D-ribose + adenine | - |
? | |
5'-deoxyadenosine + H2O | - |
Borreliella burgdorferi | 5-deoxy-D-ribose + adenine | - |
? | |
5'-methylthioadenosine + H2O | - |
Escherichia coli | 5-methylthio-D-ribose + adenine | - |
? | |
5'-methylthioadenosine + H2O | - |
Borreliella burgdorferi | 5-methylthio-D-ribose + adenine | - |
? | |
S-adenosyl-L-homocysteine + H2O | - |
Escherichia coli | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
? | |
S-adenosyl-L-homocysteine + H2O | - |
Borreliella burgdorferi | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Escherichia coli |
dimer | - |
Borreliella burgdorferi |
Synonyms | Comment | Organism |
---|---|---|
Bgp | - |
Borreliella burgdorferi |
methylthioadenosine/S-adenosylhomocysteine nucleosidase | - |
Escherichia coli |
methylthioadenosine/S-adenosylhomocysteine nucleosidase | - |
Borreliella burgdorferi |
MTA/SAH nucleosidase | - |
Escherichia coli |
MTA/SAH nucleosidase | - |
Borreliella burgdorferi |
Pfs | - |
Escherichia coli |
Pfs | - |
Borreliella burgdorferi |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the synthesis of 4,5-dihdroxy-2,3-pentanedione from methionine. S-adenosyl-L-homocysteine hydrolysis by MTA/SAH nucleosidase yields S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, a precursor of autoinducer-2 synthesis, a quorum-sensing signal that governs a variety of bacterial phenotypes such as virulence and biofilm formation | Escherichia coli |
physiological function | the enzyme is involved in the synthesis of 4,5-dihdroxy-2,3-pentanedione from methionine. S-adenosyl-L-homocysteine hydrolysis by MTA/SAH nucleosidase yields S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, a precursor of autoinducer-2 synthesis, a quorum-sensing signal that governs a variety of bacterial phenotypes such as virulence and biofilm formation | Borreliella burgdorferi |