Literature summary for 3.2.2.6 extracted from

Shu, B.; Feng, Y.; Gui, Y.; Lu, Q.; Wei, W.; Xue, X.; Sun, X.; He, W.; Yang, J.; Dai, C.
Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB signaling suppression (2018), Cell. Signal., 42, 249-258 .

Search for more literature for 3.2.2.6

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P56528	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CD38	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	in cultured macrophages, lipopolysaccharide LPS can upregulate CD38 expression in time- and dose-dependent manner	up

General Information

General Information	Comment	Organism
physiological function	in cultured macrophages, lipopolysaccharide LPS can upregulate CD38 expression in time- and dose-dependent manner. Knocking down or blockade of CD38 in macrophages inhibits LPS-induced macrophage M1 polarization accompanied by diminished NF-kappaB signaling activation. In a mouse model with LPS-induced acute kidney injury, blocking CD38 with quercetin significantly relieves kidney dysfunction, kidney pathological changes as well as inflammatory cell accumulation	Mus musculus

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Release 2023.1 (January 2023)