Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.6 extracted from

  • Ma, Y.; Cao, W.; Wang, L.; Jiang, J.; Nie, H.; Wang, B.; Wei, X.; Ying, W.
    Basal CD38/cyclic ADP-ribose-dependent signaling mediates ATP release and survival of microglia by modulating connexin 43 hemichannels (2014), Glia, 62, 943-955.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic ADP-ribose + H2O Mus musculus
-
ADP-D-ribose
-
?
additional information Mus musculus CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells ?
-
?
NAD+ Mus musculus
-
cyclic ADP-ribose + nicotinamide
-
?
NAD+ + H2O Mus musculus overall reaction ADP-D-ribose + nicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P56528
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Mus musculus
-
brain
-
Mus musculus
-
BV-2 cell
-
Mus musculus
-
microglia primary microglial cultures as cellular models Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic ADP-ribose + H2O
-
Mus musculus ADP-D-ribose
-
?
additional information CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells Mus musculus ?
-
?
NAD+
-
Mus musculus cyclic ADP-ribose + nicotinamide
-
?
NAD+ + H2O overall reaction Mus musculus ADP-D-ribose + nicotinamide
-
?

Synonyms

Synonyms Comment Organism
CD38
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

General Information

General Information Comment Organism
malfunction CD38 reductions lead to microglial apoptosis. inhibition of CD38/cADPR-dependent signaling by CD38 silencing or 8-bromo-cADPR, a ryanodine receptor antagonist, produced significant ATP release from BV2 microglia. Cx43 small interfering RNA and Cx43 hemichannel blocker 18-alpha-glycyrrhetinic acid completely prevented the CD38 silencing or 8-bromo-cADPR-induced ATP release. Prevention of the ATP release might also be due to P2X7 receptor antagonists. Key role of ATP release in the microglial apoptosis induced by decreased CD38/cADPR-dependent signaling, overview Mus musculus
physiological function CD38 is an ectoenzyme that consumes NAD+ to produce cyclic ADP-ribose, a potent agonist of ryanodine receptors. Basal CD38/cyclic ADP-ribose-dependent signaling plays a key role in ATP release, which mediates basal survival of microglia, overview Mus musculus