Application | Comment | Organism |
---|---|---|
analysis | NADase fused to an amino-terminal fragment of anthrax toxin lethal factor is translocated across a synthetic lipid bilayer in vitro in the presence of anthrax toxin protective antigen in a pH-dependent manner. Exposure of human oropharyngeal keratinocytes to the fused NADase in the presence of protective antigen results in cytosolic delivery of NADase activity, inhibition of protein synthesis, and cell death | Streptococcus pyogenes serotype M3 |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes serotype M3 | A0A0H2UTN5 | - |
- |
Purification (Comment) | Organism |
---|---|
method for purification of enzymatically active NADase fused to an amino-terminal fragment of anthrax toxin lethal factor | Streptococcus pyogenes serotype M3 |
General Information | Comment | Organism |
---|---|---|
physiological function | anthrax toxin-mediated delivery of NADase in an amount comparable to that observed during in vitro infection with live group A Streptococcus rescues the defective intracellular survival of NADase-deficient group A Streptococcus and increases the survival of streptolysin-deficient group A Streptococcus | Streptococcus pyogenes serotype M3 |