Literature summary for 3.2.2.5 extracted from

Chandrasekaran, S.; Caparon, M.
The NADase-negative variant of the Streptococcus pyogenes toxin NAD+ glycohydrolase induces JNK1-mediated programmed cellular necrosis (2016), mBio, 7, e02215 .

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Organism

Organism	UniProt	Comment	Textmining
Streptococcus pyogenes	-	-	-
Streptococcus pyogenes JRS4	-	-	-

General Information

General Information	Comment	Organism
physiological function	a natural NADase variant lacking catalytic activity induces necrosis in HeLa epithelial cells associated with depolarization of mitochondrial membranes, activation of NF-kappaB, and the generation of reactive oxygen species. RNAi silencing of mitogen-activated protein kinase subfamily JNK protects cells from NADase- SPN-mediated necrosis. SPN acts with streptolysin O to elicit necrosis through two different mechanisms depending on its NADase activity, i.e., metabolic (NADasex02) or programmed (NADase-), leading to distinct inflammatory profiles	Streptococcus pyogenes

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Release 2023.1 (January 2023)