Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes | - |
- |
- |
Streptococcus pyogenes JRS4 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
SPN | - |
Streptococcus pyogenes |
General Information | Comment | Organism |
---|---|---|
physiological function | SPN modifies several streptolysin SLO and NAD+-dependent host cell responses in patterns that correlate with NADase activity. SLO pore formation results in hyperactivation of poly-ADP-ribose polymerase-1 (PARP-1) and production of polymers of poly-ADP-ribose (PAR). SPN NADase activity moderates PARP-1 activation and blocks accumulation of PAR, these processes continued unabated in the presence of NADase-inactive SPN. PAR production is initially independent of NADase activity, but PAR rapidly disappears in the presence of NADase-active SPN, host cell ATP is depleted and the proinflammatory mediator High-Mobility Group Box-1 (HMGB1) protein is released from the nucleus by a PARP-1 dependent mechanism | Streptococcus pyogenes |