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Literature summary for 3.2.2.5 extracted from

  • Whitney, J.C.; Quentin, D.; Sawai, S.; LeRoux, M.; Harding, B.N.; Ledvina, H.E.; Tran, B.Q.; Robinson, H.; Goo, Y.A.; Goodlett, D.R.; Raunser, S.; Mougous, J.D.
    An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells (2015), Cell, 163, 607-619 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Pseudomonas aeruginosa

Crystallization (Commentary)

Crystallization (Comment) Organism
to 1.4 A resolution, in complex with binding protein Tsi6 Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Pseudomonas aeruginosa 16020
-

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9I739
-
-
Pseudomonas aeruginosa DSM 22644 Q9I739
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information nicotinamide and ADP-ribose are the only detectable products, no cyclization is found, i.e. no reaction of EC 3.2.2.6 Pseudomonas aeruginosa ?
-
?
additional information nicotinamide and ADP-ribose are the only detectable products, no cyclization is found, i.e. no reaction of EC 3.2.2.6 Pseudomonas aeruginosa DSM 22644 ?
-
?
NAD+ + H2O
-
Pseudomonas aeruginosa ADP-D-ribose + nicotinamide
-
?
NAD+ + H2O
-
Pseudomonas aeruginosa DSM 22644 ADP-D-ribose + nicotinamide
-
?
NADP+ + H2O
-
Pseudomonas aeruginosa phospho-ADP-ribose + nicotinamide
-
?
NADP+ + H2O
-
Pseudomonas aeruginosa DSM 22644 phospho-ADP-ribose + nicotinamide
-
?

Synonyms

Synonyms Comment Organism
PA0093
-
Pseudomonas aeruginosa
Tse6
-
Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
NAD+ degradation rates for NAD+ and NADP+ are similar Pseudomonas aeruginosa
NADP+ degradation rates for NAD+ and NADP+ are similar Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function integral membrane toxin Tse6 acts on target cells by depleting cells of the related cofactors NAD+ and NADP+, thereby simultaneously inhibiting anabolic and catabolic processes required for homeostasis and growth. Tse6 requires interaction with translation elongation factor Tu for delivery into recipient cells Pseudomonas aeruginosa