Cloned (Comment) | Organism |
---|---|
- |
Pseudomonas aeruginosa |
Crystallization (Comment) | Organism |
---|---|
to 1.4 A resolution, in complex with binding protein Tsi6 | Pseudomonas aeruginosa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Pseudomonas aeruginosa | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | Q9I739 | - |
- |
Pseudomonas aeruginosa DSM 22644 | Q9I739 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | nicotinamide and ADP-ribose are the only detectable products, no cyclization is found, i.e. no reaction of EC 3.2.2.6 | Pseudomonas aeruginosa | ? | - |
? | |
additional information | nicotinamide and ADP-ribose are the only detectable products, no cyclization is found, i.e. no reaction of EC 3.2.2.6 | Pseudomonas aeruginosa DSM 22644 | ? | - |
? | |
NAD+ + H2O | - |
Pseudomonas aeruginosa | ADP-D-ribose + nicotinamide | - |
? | |
NAD+ + H2O | - |
Pseudomonas aeruginosa DSM 22644 | ADP-D-ribose + nicotinamide | - |
? | |
NADP+ + H2O | - |
Pseudomonas aeruginosa | phospho-ADP-ribose + nicotinamide | - |
? | |
NADP+ + H2O | - |
Pseudomonas aeruginosa DSM 22644 | phospho-ADP-ribose + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PA0093 | - |
Pseudomonas aeruginosa |
Tse6 | - |
Pseudomonas aeruginosa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | degradation rates for NAD+ and NADP+ are similar | Pseudomonas aeruginosa | |
NADP+ | degradation rates for NAD+ and NADP+ are similar | Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
physiological function | integral membrane toxin Tse6 acts on target cells by depleting cells of the related cofactors NAD+ and NADP+, thereby simultaneously inhibiting anabolic and catabolic processes required for homeostasis and growth. Tse6 requires interaction with translation elongation factor Tu for delivery into recipient cells | Pseudomonas aeruginosa |