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Literature summary for 3.2.2.5 extracted from

  • Zhu, L.; Olsen, R.J.; Lee, J.D.; Porter, A.R.; DeLeo, F.R.; Musser, J.M.
    Contribution of secreted NADase and streptolysin O to the pathogenesis of epidemic serotype M1 Streptococcus pyogenes infections (2017), Am. J. Pathol., 187, 605-613 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes serotype M1 Q7DAN2
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Synonyms

Synonyms Comment Organism
Nga
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Streptococcus pyogenes serotype M1

General Information

General Information Comment Organism
physiological function isogenic mutants lacking NADase SPN, streptolysin SLO, and both toxins are equally impaired in ability to cause necrotizing myositis in mouse models. Mutants lacking either SPN or SLO are significantly attenuated in the bacteremia and soft tissue infection models, and the mutant strain lacking production of both toxins is further attenuated. The mutant strain lacking both SPN and SLO production is severely attenuated in ability to resist killing by human polymorphonuclear leukocytes. None of the isogenic mutant strains has a growth defect when cultured in Todd-Hewitt broth supplemented with 0.2% yeast extract Streptococcus pyogenes serotype M1