Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes serotype M1 | Q7DAN2 | - |
- |
Synonyms | Comment | Organism |
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Nga | - |
Streptococcus pyogenes serotype M1 |
General Information | Comment | Organism |
---|---|---|
physiological function | isogenic mutants lacking NADase SPN, streptolysin SLO, and both toxins are equally impaired in ability to cause necrotizing myositis in mouse models. Mutants lacking either SPN or SLO are significantly attenuated in the bacteremia and soft tissue infection models, and the mutant strain lacking production of both toxins is further attenuated. The mutant strain lacking both SPN and SLO production is severely attenuated in ability to resist killing by human polymorphonuclear leukocytes. None of the isogenic mutant strains has a growth defect when cultured in Todd-Hewitt broth supplemented with 0.2% yeast extract | Streptococcus pyogenes serotype M1 |