Literature summary for 3.2.2.5 extracted from

Iqbal, J.; Zaidi, M.
CD38 is required for priming by TNF-alpha: a mechanism for extracellular coordination of cell fate (2007), Am. J. Physiol. Renal Physiol., 292, F1283-F1290.

Search for more literature for 3.2.2.5

Application

Application	Comment	Organism
medicine	tumor necrosis factor alpha upregulates CD38. Induced CD38 expression enhances inflammatory gene expression by decreasing ERK1/2 phosphorylation and increasing NF kappaB activation. It negatively affects the expression of osteoclast markers. CD38 may reduce osteoclastogenesis and increase inflammatory gene induction by decreasing cellular histone deacetylase activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform CD38	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	from bone marrow. Tumor necrosis factor alpha upregulates CD38. Induced CD38 expression enhances inflammatory gene expression by decreasing ERK1/2 phosphorylation and increasing NF kappaB activation. It negatively affects the expression of osteoclast markers. CD38 may reduce osteoclastogenesis and increase inflammatory gene induction by decreasing cellular histone deacetylase activity	Mus musculus	-

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Release 2023.1 (January 2023)