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Literature summary for 3.2.2.31 extracted from

  • Trasvina-Arenas, C.H.; Lopez-Castillo, L.M.; Sanchez-Sandoval, E.; Brieba, L.G.
    Dispensability of the [4Fe-4S] cluster in novel homologues of adenine glycosylase MutY (2016), FEBS J., 283, 521-540 .
    View publication on PubMed
Search for more literature for 3.2.2.31

Cloned(Commentary)

Cloned (Comment) Organism
expressed as chimeric glycosylase in Escherichia coli JM101 cells Entamoeba histolytica
expressed as chimeric glycosylase in Escherichia coli JM101 cells Levilactobacillus brevis

Protein Variants

Protein Variants Comment Organism
D149A active site mutant Levilactobacillus brevis
D179A active site mutant Entamoeba histolytica
E48A active site mutant Levilactobacillus brevis
E48A/D149A active site mutant Levilactobacillus brevis
E78A active site mutant Entamoeba histolytica
E78A/D179A active site mutant Entamoeba histolytica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O Entamoeba histolytica
-
 adenine + DNA with apurinic site
-
 ?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O Levilactobacillus brevis
-
 adenine + DNA with apurinic site
-
 ?
DNA containing an adenine:guanine mismatch + H2O Entamoeba histolytica
-
 adenine + DNA with apurinic site
-
 ?
DNA containing an adenine:guanine mismatch + H2O Levilactobacillus brevis
-
 adenine + DNA with apurinic site
-
 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
-
-
-
Levilactobacillus brevis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
-
 Entamoeba histolytica adenine + DNA with apurinic site
-
 ?
DNA containing an adenine:7,8-dihydro-8-oxoadenine mismatch + H2O
-
 Levilactobacillus brevis adenine + DNA with apurinic site
-
 ?
DNA containing an adenine:guanine mismatch + H2O
-
 Entamoeba histolytica adenine + DNA with apurinic site
-
 ?
DNA containing an adenine:guanine mismatch + H2O
-
 Levilactobacillus brevis adenine + DNA with apurinic site
-
 ?

Synonyms

Synonyms Comment Organism
mutY
-
 Entamoeba histolytica
mutY
-
 Levilactobacillus brevis

Cofactor

Cofactor Comment Organism Structure
[4Fe-4S]-center the [4Fe-4S] cluster is not necessary for the catalytic activity of the enzyme Entamoeba histolytica
[4Fe-4S]-center the [4Fe-4S] cluster is not necessary for the catalytic activity of the enzyme Levilactobacillus brevis