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Literature summary for 3.2.2.31 extracted from

  • Porello, S.L.; Leyes, A.E.; David, S.S.
    Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates (1998), Biochemistry, 37, 14756-14764 .
    View publication on PubMed
Search for more literature for 3.2.2.31

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O the enzyme shows 6fold faster adenine removal compared to DNA containing a guanine:adenine mismatch. However, under conditions where the concentration of the enzyme is much lower than the concentration of DNA, 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine substrates are not quantitatively converted to product due to the inefficient turnover resulting from slow product release Escherichia coli ?
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 ?
DNA containing a guanine:adenine mismatch + H2O
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 Escherichia coli ?
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 ?

Synonyms

Synonyms Comment Organism
adenine glycosylase
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 Escherichia coli
mutY
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 Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in the prevention of DNA mutations resulting from the presence of the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine in DNA by the removal of misincorporated adenine residues in 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispairs and also exhibits adenine glycosylase activity toward adenine in guanine:adenine and cytosine:adenine mismatches Escherichia coli