Literature summary for 3.2.2.30 extracted from

Banco, M.T.; Mishra, V.; Ostermann, A.; Schrader, T.E.; Evans, G.B.; Kovalevsky, A.; Ronning, D.R.
Neutron structures of the Helicobacter pylori 5-methylthioadenosine nucleosidase highlight proton sharing and protonation states (2016), Proc. Natl. Acad. Sci. USA, 113, 13756-13761 .

Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of wild-type cocrystallized with S-adenosylhomocysteine, formycin A, and (3R,4S)-4-(4-chlorophenylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine as well as one structure of inactive variant D198N cocrystallized with S-adenosylhomocysteine. Mechanism of D198 pKa elevation is through the sharing of a proton with atom N7 of the adenine moiety possessing unconventional hydrogen-bond geometry	Helicobacter pylori

Crystallization (Comment)

Organism

structures of wild-type cocrystallized with S-adenosylhomocysteine, formycin A, and (3R,4S)-4-(4-chlorophenylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine as well as one structure of inactive variant D198N cocrystallized with S-adenosylhomocysteine. Mechanism of D198 pKa elevation is through the sharing of a proton with atom N7 of the adenine moiety possessing unconventional hydrogen-bond geometry

Helicobacter pylori

Protein Variants

Protein Variants	Comment	Organism
D198N	inactive	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	Q9ZMY2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-amino-6-deoxyfutalosine + H2O	-	Helicobacter pylori	dehypoxanthine futalosine + adenine	-	?

Synonyms

Synonyms	Comment	Organism
MTAN	-	Helicobacter pylori
MtnN	-	Helicobacter pylori

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Release 2023.1 (January 2023)