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Literature summary for 3.2.2.3 extracted from
- Identification of proton-pump inhibitor drugs that inhibit Trichomonas vaginalis uridine nucleoside ribohydrolase (2014), Bioorg. Med. Chem. Lett., 24, 1080-1084.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | molecular mechanism for the in vitro antitrichomonal activity of these proton-pump inhibitors, overview | Trichomonas vaginalis | |
| Omeprazole | an enzyme and a proton-pump inhibitor | Trichomonas vaginalis |  |
| pantoprazole | an enzyme and a proton-pump inhibitor | Trichomonas vaginalis | |
| rabeprazole | an enzyme and a proton-pump inhibitor | Trichomonas vaginalis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trichomonas vaginalis | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UNH | - |
Trichomonas vaginalis |
| uridine nucleoside ribohydrolase | - |
Trichomonas vaginalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperrature | Trichomonas vaginalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Trichomonas vaginalis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
pH 6.5, 22°C | Trichomonas vaginalis | rabeprazole | |
| 0.0023 | - |
pH 6.5, 22°C | Trichomonas vaginalis | Omeprazole | |
| 0.0145 | - |
pH 6.5, 22°C | Trichomonas vaginalis | pantoprazole | |
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Release 2023.1 (January 2023)
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