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Literature summary for 3.2.2.29 extracted from
- Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA (2012), Nat. Chem. Biol., 8, 328-330.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with duplex DNA containing either 5-carboxylcytosine or a 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-carbonylcytosine, hanging drop vapor diffusion method, using | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| N140A | inactive | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
5-carboxylcytosine + double-stranded DNA with abasic site | - |
? |  |
| thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13569 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-carboxylcytosine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | 5-carboxylcytosine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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