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Literature summary for 3.2.2.29 extracted from

  • Ma, J.Y.; Zhao, K.; OuYang, Y.C.; Wang, Z.B.; Luo, Y.B.; Hou, Y.; Schatten, H.; Shen, W.; Sun, Q.Y.
    Exogenous thymine DNA glycosylase regulates epigenetic modifications and meiotic cell cycle progression of mouse oocytes (2015), Mol. Hum. Reprod., 21, 186-194.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm before germinal vesicle breakdown the enzyme is released from the nucleus into the cytoplasm Mus musculus 5737
-
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O Mus musculus
-
thymine + double-stranded DNA with abasic site
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymine-mismatched double-stranded DNA + H2O
-
Mus musculus thymine + double-stranded DNA with abasic site
-
?

Synonyms

Synonyms Comment Organism
TDG
-
Mus musculus
thymine DNA glycosylase
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme functions in base excision repair and also acts as a key enzyme that participates in active DNA demethylation. Aberrant enzyme expression causes epigenetic modifications and meiotic cell cycle arrest of mouse oocytes Mus musculus