Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition of TDG activity on methylated G:IU mispairs by the methyl binding domain | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | thymine DNA glycosylase and methyl binding domain protein 4 act on G:IU, i.e. iododeoxyuridine, but not A:IU, mispairs and are functionally complementary to each other | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | thymine DNA glycosylase and methyl binding domain protein 4 act on G:IU, i.e. iododeoxyuridine, but not A:IU, mispairs and are functionally complementary to each other | Homo sapiens | ? | - |
? | |
additional information | IUdR is a thymidine analogue which has been used in the clinic as a radiosensitizer. Following active cell membrane transport, IUdR is sequentially phosphorylated to IdUTP which competes with thymidine, TdR, for DNA incorporation. G:IU mispair is a substrate for thymidine DNA glycosylase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TDG | - |
Homo sapiens |
thymine DNA glycosylase | - |
Homo sapiens |