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Literature summary for 3.2.2.29 extracted from

  • Kunz, C.; Focke, F.; Saito, Y.; Schuermann, D.; Lettieri, T.; Selfridge, J.; Schär, P.
    Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil (2009), PLoS Biol., 7, e91.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.29

Application

Application Comment Organism
medicine 5-fluorouracil is used in clinical cancer therapy. The status of TDG expression in a cancer is likely to determine its response to 5-fluorouracil-based chemotherapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
HeLa cell clones either stably transfected with a construct overexpressing human TDG from a cytomegalovirus promoter or with the corresponding vector only Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inactivation of TDG significantly increases resistance of human cancer cells towards 5-fluorouracil. Excision of DNA-incorporated 5-fluorouracil by TDG generates persistent DNA strand breaks, delays S-phase progression, and activates DNA damage signaling. The repair of 5-fluorouracilĀ–induced DNA strand breaks is more efficient in the absence of TDG. Excision of 5-fluorouracil by TDG (but not by uracil DNA glycosylases (UNG2 and SMUG1)) prevents efficient downstream processing of the repair intermediate, thereby mediating DNA-directed cytotoxicity ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q13569
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inactivation of TDG significantly increases resistance of human cancer cells towards 5-fluorouracil. Excision of DNA-incorporated 5-fluorouracil by TDG generates persistent DNA strand breaks, delays S-phase progression, and activates DNA damage signaling. The repair of 5-fluorouracilĀ–induced DNA strand breaks is more efficient in the absence of TDG. Excision of 5-fluorouracil by TDG (but not by uracil DNA glycosylases (UNG2 and SMUG1)) prevents efficient downstream processing of the repair intermediate, thereby mediating DNA-directed cytotoxicity Homo sapiens ?
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Synonyms

Synonyms Comment Organism
TDG
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 Homo sapiens
thymine DNA glycosylase
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 Homo sapiens