Literature summary for 3.2.2.23 extracted from

Dunn, A.R.; Kad, N.M.; Nelson, S.R.; Warshaw, D.M.; Wallace, S.S.
Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA (2011), Nucleic Acids Res., 39, 7487-7498.

Search for more literature for 3.2.2.23

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
F111A	the mutant displays a significant increase in the average diffusion constant compared to the wild-type protein with no enzymatic activity on DNA containing 8-oxoguanine residues opposite cytosine. The mutant has little or no ability to form a Schiff base with 8-oxoguanine residues opposite cytosine or 5,6-dihydrouracil opposite guanine compared to wild type enzyme	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 8-oxoguanine residues + H2O	8-oxoguanine residues opposite cytosine	Escherichia coli	8-oxoguanine + DNA	-	?
additional information	formamidopyrimidine DNA glycosylase is specific for oxidized purines	Escherichia coli	?	-	?

Synonyms

Synonyms	Comment	Organism
formamidopyrimidine DNA glycosylase	-	Escherichia coli
FPG	-	Escherichia coli

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Release 2023.1 (January 2023)