Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.23 extracted from

  • Le Bihan, Y.V.; Angeles Izquierdo, M.; Coste, F.; Aller, P.; Culard, F.; Gehrke, T.H.; Essalhi, K.; Carell, T.; Castaing, B.
    5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases (2011), Nucleic Acids Res., 39, 6277-6290.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.23

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BH540 Lactococcus lactis

Inhibitors

Inhibitors Comment Organism Structure
DNA containing 2-deoxyribonolactone residues suicide inhibitor for formamidopyrimidine-DNA glycosylase Lactococcus lactis
DNA containing 5-hydroxy-5-methylhydantoin residues suicide inhibitor for formamidopyrimidine-DNA glycosylase Lactococcus lactis

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 2,6-diamino-4-hydroxy-5-formamidopyrimidine residues + H2O
-
 Lactococcus lactis 2,6-diamino-4-hydroxy-5-formamidopyrimidine + DNA
-
 ?
DNA containing 5-hydroxy-5-methylhydantoin residues opposite cytosine + H2O excellent substrate when the lesion is opposite a cytosine, poor substrate when the lesion is opposite a adenine Lactococcus lactis 5-hydroxy-5-methylhydantoin + DNA
-
 ?
DNA containing 8-oxo-7,8-dihydropurine + H2O poor substrate when the lesion is opposite a cytosine Lactococcus lactis 8-oxo-7,8-dihydropurine + DNA
-
 ?
additional information the enzyme is a DNA glycosylase/AP lyase specific for oxidized purines such as 8-oxo-7,8-dihydropurines and imidazole-ring opened purines (2,6-diamino-4-hydroxy-5-formamidopyrimidine and formamidopyrimidine derived from adenine) Lactococcus lactis ?
-
 ?

Synonyms

Synonyms Comment Organism
Fapy DNA glycosylase
-
 Lactococcus lactis
formamidopyrimidine-DNA glycosylase
-
 Lactococcus lactis
FPG
-
 Lactococcus lactis
MutM
-
 Lactococcus lactis