Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
22000 | - |
1 * 40000 + 1 * 22000, chain B and chain A, SDS-PAGE | Corynebacterium diphtheriae |
40000 | - |
1 * 40000 + 1 * 22000, chain B and chain A, SDS-PAGE | Corynebacterium diphtheriae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium diphtheriae | - |
- |
- |
Corynebacterium diphtheriae PW-8 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Blue Sepharose column chromatography | Corynebacterium diphtheriae |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 40000 + 1 * 22000, chain B and chain A, SDS-PAGE | Corynebacterium diphtheriae |
Synonyms | Comment | Organism |
---|---|---|
diphtheria toxin | - |
Corynebacterium diphtheriae |
General Information | Comment | Organism |
---|---|---|
physiological function | Corynebacterium diphtheriae secretes the diphtheria toxin, a virulence factor that can be lethal to the human organism at doses below 0.0001 mg/kg of body weight. During infections, the toxin binds to the cell membrane and subunit A will enter the cytoplasm and catalyze the ADP-ribosylation and inactivation of elongation factor 2 thus killing the eukaryotic cell by inhibiting ribosomal translocation | Corynebacterium diphtheriae |