Application | Comment | Organism |
---|---|---|
biotechnology | ricin is a prototype for the construction of chimeric molecules, called immunotoxins, based on the structure of the A-B toxins. An application of the ricin B as a carrier is the fusion and expression with different viral antigens used for vaccination therapies. A fusion protein combining the genes for endotoxin of Bacillus thuringiensis with the ricin B chain, and transgenic rice and maize plants expressing the fusion protein are more toxic to insects than plants containing the toxin gene alone | Ricinus communis |
biotechnology | saporin is fused to ubiquitin to allow a rapid degradation of the toxin via the ubiquitin-proteasome system in non-target cells. Saporin is the preferred toxin for constructing anti-neuronal immunotoxins and neuropeptide-toxin conjugates. The saporin gene is also used as a tool for suicide gene therapy | Saponaria officinalis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
x * 36000 | Ricinus communis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ricinus communis | - |
- |
- |
Saponaria officinalis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Ricinus communis |
glycoprotein | - |
Saponaria officinalis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endosperm | - |
Ricinus communis | - |
endosperm | - |
Saponaria officinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
28S rRNA + H2O | the protein removes a specific adenine residue from the ribosomal RNA inducing the block of protein synthesis by inhibiting the binding of the elongation factor 2 | Ricinus communis | ? | - |
? | |
28S rRNA + H2O | the protein removes a specific adenine residue from the ribosomal RNA inducing the block of protein synthesis by inhibiting the binding of the elongation factor 2 | Saponaria officinalis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 36000 | Ricinus communis |
Synonyms | Comment | Organism |
---|---|---|
ribosome inactivating protein | - |
Ricinus communis |
ribosome inactivating protein | - |
Saponaria officinalis |
ricin | a type II ribosome inactivating protein | Ricinus communis |
RIP | - |
Ricinus communis |
RIP | - |
Saponaria officinalis |
saporin | - |
Saponaria officinalis |