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Literature summary for 3.2.2.22 extracted from

  • Giansanti, F.; Di Leandro, L.; Koutris, I.; Cialfi, A.; Benedetti, E.; Laurenti, G.; Pitari, G.; Ippoliti, R.
    Ricin and saporin: Plant enzymes for the research and the clinics (2010), Curr. Chem. Biol., 4, 99-107.
No PubMed abstract available

Application

Application Comment Organism
biotechnology ricin is a prototype for the construction of chimeric molecules, called immunotoxins, based on the structure of the A-B toxins. An application of the ricin B as a carrier is the fusion and expression with different viral antigens used for vaccination therapies. A fusion protein combining the genes for endotoxin of Bacillus thuringiensis with the ricin B chain, and transgenic rice and maize plants expressing the fusion protein are more toxic to insects than plants containing the toxin gene alone Ricinus communis
biotechnology saporin is fused to ubiquitin to allow a rapid degradation of the toxin via the ubiquitin-proteasome system in non-target cells. Saporin is the preferred toxin for constructing anti-neuronal immunotoxins and neuropeptide-toxin conjugates. The saporin gene is also used as a tool for suicide gene therapy Saponaria officinalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
x * 36000 Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis
-
-
-
Saponaria officinalis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Ricinus communis
glycoprotein
-
Saponaria officinalis

Source Tissue

Source Tissue Comment Organism Textmining
endosperm
-
Ricinus communis
-
endosperm
-
Saponaria officinalis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
28S rRNA + H2O the protein removes a specific adenine residue from the ribosomal RNA inducing the block of protein synthesis by inhibiting the binding of the elongation factor 2 Ricinus communis ?
-
?
28S rRNA + H2O the protein removes a specific adenine residue from the ribosomal RNA inducing the block of protein synthesis by inhibiting the binding of the elongation factor 2 Saponaria officinalis ?
-
?

Subunits

Subunits Comment Organism
? x * 36000 Ricinus communis

Synonyms

Synonyms Comment Organism
ribosome inactivating protein
-
Ricinus communis
ribosome inactivating protein
-
Saponaria officinalis
ricin a type II ribosome inactivating protein Ricinus communis
RIP
-
Ricinus communis
RIP
-
Saponaria officinalis
saporin
-
Saponaria officinalis