Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-deazaadenine-9-methylene-N-hydroxypyrrolidine | transition state analogue inhibitors contraining 9-deazaadenine-9-methylene-N-hydroxypyrrolidine. The tight-binding inhibitors mimic the sarcin-ricin recognition loop of 28S rRNA and the dissociative ribocation transition state established for RTA catalysis. RTA has a unique purine-binding geometry with quadruple pi-stacking interactions between adjacent adenine and guanine bases and 2 conserved tyrosines. An arginine at one end of the pi-stack provides cationic polarization and enhanced leaving group ability to the susceptible adenine. Inhibition mechanism, overview | Ricinus communis | |
9-deazaadenine-9-methylene-N-hydroxypyrrolidine | transition state analogue inhibitors containing 9-deazaadenine-9-methylene-N-hydroxypyrrolidine. The tight-binding inhibitors mimic the sarcin-ricin recognition loop of 28S rRNA and the dissociative ribocation transition state. SAP has a unique purine-binding geometry with quadruple pi-stacking interactions between adjacent adenine and guanine bases and 2 conserved tyrosines. An arginine at one end of the pi-stack provides cationic polarization and enhanced leaving group ability to the susceptible adenine. Inhibition mechanism, overview | Saponaria officinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Ricinus communis | RTA catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death | ? | - |
? | |
additional information | Saponaria officinalis | SAP catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ricinus communis | P02879 | - |
- |
Saponaria officinalis | Q2QEH4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seed | - |
Ricinus communis | - |
seed | - |
Saponaria officinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | RTA catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death | Ricinus communis | ? | - |
? | |
additional information | SAP catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death | Saponaria officinalis | ? | - |
? | |
additional information | RTA catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis, substrate binding structure, overview | Ricinus communis | ? | - |
? | |
additional information | SAP catalyzes adenosine depurination of 28S rRNA to inhibit protein synthesis, substrate binding structure, overview | Saponaria officinalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ribosome-inactivating protein | - |
Ricinus communis |
ribosome-inactivating protein | - |
Saponaria officinalis |
ricin A | - |
Ricinus communis |
RIP | - |
Ricinus communis |
RIP | - |
Saponaria officinalis |
RTA | - |
Ricinus communis |
SAP | - |
Saponaria officinalis |
saporin-L1 | - |
Saponaria officinalis |