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Literature summary for 3.2.2.22 extracted from

  • Parikh, B.A.; Tortora, A.; Li, X.P.; Tumer, N.E.
    Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA (2008), J. Biol. Chem., 283, 6145-6153.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of ricin A chain in Saccharomyces cerevisiae Ricinus communis

Protein Variants

Protein Variants Comment Organism
E177K mutant in ricin A chain that retains some catalytic activity but does not kill yeast cells when expresed in Saccharomyces cerevisiae. Contrary to wild-type, mutant is not able to inhibit activation of unfolded protein response Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ricin A chain expressed in Saccharomyces cerevisiae inhibits activation of unfolded protein response by preventing HAC1 mRNA splicing. The inability to activate unfolded protein response contributes to ricin cytotoxicity Ricinus communis ?
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