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Literature summary for 3.2.2.22 extracted from

  • Ayub, M.J.; Smulski, C.R.; Ma, K.W.; Levin, M.J.; Shaw, P.C.; Wong, K.B.
    The C-terminal end of P proteins mediates ribosome inactivation by trichosanthin but does not affect the pokeweed antiviral protein activity (2008), Biochem. Biophys. Res. Commun., 369, 314-319.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
scFvC5 single chain fragment variable antibody, blocks interaction between trichosanthin K173, R174, and K177 residues and ribosomal P proteins protecting ribosomes from inactivation Trichosanthes kirilowii

Organism

Organism UniProt Comment Textmining
Phytolacca americana P10297 isoform pokeweed antiviral protein, i.e. PAP
-
Trichosanthes kirilowii P09989 isoform trichosanthin, i.e. TCS
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
28Sdelta rRNA + H2O
-
Phytolacca americana ? depurination of the A51 residue of Trypanosoma cruzi 28Sdelta rRNA, the C-terminal end of ribosomal P proteins is not required for full activity ?
28Sdelta rRNA + H2O
-
Trichosanthes kirilowii ? depurination of the A51 residue of Trypanosoma cruzi 28Sdelta rRNA, the C-terminal end of ribosomal P proteins is required for full activity of trichosanthin ?

Synonyms

Synonyms Comment Organism
pokeweed antiviral protein
-
Phytolacca americana
TCS
-
Trichosanthes kirilowii