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Literature summary for 3.2.2.21 extracted from

  • Hollis, T.; Ichikawa, Y.; Ellenberger, T.
    DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA (2000), EMBO J., 19, 758-766.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
2.5 A crystal structure colmplexed to DNA, crystals belong to space group P3(1)21, cell dimensions a = B = 82.4 A and c = 199.7 A Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
DNA containing 1-azaribose
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Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Escherichia coli DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli P04395
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
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Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?

Synonyms

Synonyms Comment Organism
AlkA protein
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Escherichia coli
helix-hairpin-helix DNA glycosylase
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Escherichia coli