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Literature summary for 3.2.2.21 extracted from

  • Wyatt, M.D.; Allan, J.M.; Lau, A.Y.; Ellenberger, T.E.; Samson, L.D.
    3-Methyladenine DNA glycosylases: structure, function, and biological importance (1999), Bioessays, 21, 668-676.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Escherichia coli
AAG complexed to DNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Mus musculus
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Escherichia coli
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Homo sapiens
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Rattus norvegicus
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Saccharomyces cerevisiae
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Arabidopsis thaliana
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Schizosaccharomyces pombe
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Rattus norvegicus
-
rat
-
Saccharomyces cerevisiae
-
yeast
-
Schizosaccharomyces pombe
-
fission yeast
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
Mus musculus 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Homo sapiens 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Rattus norvegicus 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Saccharomyces cerevisiae 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Arabidopsis thaliana 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Schizosaccharomyces pombe 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
additional information releases 3-methyladenine, 3-methylguanine, 7-methylguanine, 7-(2-chloroethyl)guanine, 7-(2-hydroxyethyl)guanine, 1,N6-ethenoadenine, hypoxanthine, and guanine from damaged and normal DNA, adenine, thymine, cytosine,3-ethenoguanine, 8-oxoguanine, 7-(2-ethoxyethyl)guanine, O2-methylthymine, and O2-methylcytosine are not released Saccharomyces cerevisiae ?
-
?
additional information releases 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, O2-methylcytosine, 7-(2-chloroethyl)guanine, 7-(2-hydroxyethyl)guanine, 7-(2-ethoxyethyl)guanine, 1,N6-ethenoadenine, hypoxanthine, adenine, guanine, thymine and cytosine from damaged and normal DNA, 3-ethenoguanine and 8-oxoguanine are not released Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
AAG
-
Mus musculus
AAG
-
Homo sapiens
MAG
-
Saccharomyces cerevisiae