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Literature summary for 3.2.2.17 extracted from

  • Golan, G.; Zharkov, D.O.; Grollman, A.P.; Dodson, M.L.; McCullough, A.K.; Lloyd, R.S.; Shoham, G.
    Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA (2006), J. Mol. Biol., 362, 241-258.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallized at 15°C by the hanging-drop vapor-diffusion method, co-crystal structure of T4-Pdg as a reduced covalent complex with an AP site-containing duplex oligodeoxynucleotide. This high-resolution structure reveals essential precatalytic and catalytic features, including flipping of the nucleotide opposite the AP site, a sharp kink (about 66°) in the DNA at the dimer site and the covalent bond linking the enzyme to the DNA Tequatrovirus T4

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
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Synonyms

Synonyms Comment Organism
T4 pyrimidine dimer glycosylase
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Tequatrovirus T4
T4-PDG
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Tequatrovirus T4