Crystallization (Comment) | Organism |
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molecular mechanics and dynamics simulations. The ribose release process can be divided into ribose dissociation and ribose release steps The ribose dissociation includes cleavage and exchange stages, in which a metastable 6fold intermediate will recover to an 8fold coordination shell of Ca2+ . The estimated barrier for the rate-determining step of the entire reaction is 13.0 kcal/mol, which is comparable to the experimental value of 16.7 kcal/mol. The gating mechanism arising from loop1 and loop2, as well as key residues around the active pocket, plays an important role in manipulating the ribose release | Trypanosoma vivax |
Organism | UniProt | Comment | Textmining |
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Trypanosoma vivax | Q9GPQ4 | - |
- |
Synonyms | Comment | Organism |
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IAG-nucleoside hydrolase | - |
Trypanosoma vivax |