Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli WK6 cells | Trypanosoma vivax |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4S)-1-benzyl-2-(hydroxymethyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
(2R,3R,4S)-2-(hydroxymethyl)-1-(4-iodobenzyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
(2R,3R,4S)-2-(hydroxymethyl)-1-(4-nitrobenzyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
(2R,3R,4S,5S)-2-(hydroxymethyl)-5-phenylpyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(1-isoquinolinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(1-methyl-1H-1,2,3-benzotriazol-5-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(1-methyl-1H-benzimidazol-2-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(2-aminopyridin-3-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(2-naphthyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(2-quinolinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(3-cyanobenzyl)-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(3-indolyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(3-nitrobenzyl)-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(3-quinolinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(4-cyanobenzyl)-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(4-methyl-2-phenylpyrimidin-5-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(4-pyridinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(4-quinolinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(6-methoxypyridin-3-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(7-methoxy-indol-3-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(7-quinolinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(8-hydroxyquinolin-2-yl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-(8-quinolinyl)methyl-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-[3-(1H-pyrrol-1-yl)benzyl]-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-[4-(1H-pyrazol-1-yl)benzyl]-D-ribitol | - |
Trypanosoma vivax | |
1,4-dideoxy-1,4-imino-N-[4-(1H-pyrrol-1-yl)benzyl]-D-ribitol | - |
Trypanosoma vivax | |
1-[2-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]ethyl]guanidine | - |
Trypanosoma vivax | |
1-[3-[(2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]propyl]guanidine | - |
Trypanosoma vivax | |
3-deazaadenosine | - |
Trypanosoma vivax | |
immucillin-A | - |
Trypanosoma vivax | |
immucillin-H | - |
Trypanosoma vivax | |
N-(9-deazaadenin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol | - |
Trypanosoma vivax | |
N-(9-deazahypoxanthin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol | - |
Trypanosoma vivax |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma vivax | Q9GPQ4 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Superdex-200 gel filtration | Trypanosoma vivax |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl beta-D-ribofuranoside + H2O | - |
Trypanosoma vivax | 4-nitrophenol + D-ribose | - |
? | |
adenosine + H2O | preferred substrate | Trypanosoma vivax | adenine + D-ribose | - |
? | |
guanosine + H2O | preferred substrate | Trypanosoma vivax | guanine + D-ribose | - |
? | |
inosine + H2O | preferred substrate | Trypanosoma vivax | hypoxanthine + D-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IAG-NH | - |
Trypanosoma vivax |
purine specific nucleoside hydrolase | - |
Trypanosoma vivax |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000041 | - |
N-(9-deaza-adenin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0000044 | - |
N-(9-deazahypoxanthin-9-yl)methyl-1,4-dideoxy-1,4-imino-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0000108 | - |
1,4-dideoxy-1,4-imino-N-(8-quinolinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.000063 | - |
1,4-dideoxy-1,4-imino-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.00018 | - |
1,4-dideoxy-1,4-imino-N-(2-quinolinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.00072 | - |
1,4-dideoxy-1,4-imino-N-(1-methyl-1H-1,2,3-benzotriazol-5-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.00072 | - |
1,4-dideoxy-1,4-imino-N-(7-quinolinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.00075 | - |
1,4-dideoxy-1,4-imino-N-(1-isoquinolinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.001 | - |
1,4-dideoxy-1,4-imino-N-[4-(1H-pyrrol-1-yl)benzyl]-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.001 | - |
1,4-dideoxy-1,4-imino-N-(8-hydroxyquinolin-2-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0012 | - |
1,4-dideoxy-1,4-imino-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0012 | - |
1,4-dideoxy-1,4-imino-N-[4-(1H-pyrazol-1-yl)benzyl]-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.002 | - |
1,4-dideoxy-1,4-imino-N-(2-naphthyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0021 | - |
1,4-dideoxy-1,4-imino-N-(1-methyl-1H-benzimidazol-2-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0023 | - |
1,4-dideoxy-1,4-imino-N-(3-nitrobenzyl)-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0023 | - |
1,4-dideoxy-1,4-imino-N-(7-methoxy-indol-3-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0034 | - |
1,4-dideoxy-1,4-imino-N-[3-(1H-pyrrol-1-yl)benzyl]-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0038 | - |
1,4-dideoxy-1,4-imino-N-(3-cyanobenzyl)-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.0043 | - |
(2R,3R,4S)-2-(hydroxymethyl)-1-(4-iodobenzyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
0.0075 | - |
(2R,3R,4S)-2-(hydroxymethyl)-1-(4-nitrobenzyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
0.012 | - |
1,4-dideoxy-1,4-imino-N-(3-indolyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.018 | - |
1-[2-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]ethyl]guanidine | - |
Trypanosoma vivax | |
0.02 | - |
1,4-dideoxy-1,4-imino-N-(4-pyridinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.02 | - |
1,4-dideoxy-1,4-imino-N-(3-quinolinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.026 | - |
1,4-dideoxy-1,4-imino-N-(4-cyanobenzyl)-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.029 | - |
1,4-dideoxy-1,4-imino-N-(4-quinolinyl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.032 | - |
1,4-dideoxy-1,4-imino-N-(6-methoxypyridin-3-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.04 | - |
1-[3-[(2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]propyl]guanidine | - |
Trypanosoma vivax | |
0.043 | - |
1,4-dideoxy-1,4-imino-N-(4-methyl-2-phenylpyrimidin-5-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.059 | - |
(2R,3R,4S)-1-benzyl-2-(hydroxymethyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
0.12 | - |
1,4-dideoxy-1,4-imino-N-(2-aminopyridin-3-yl)methyl-D-ribitol | in 50 mM phosphate buffer, pH 7.0, at 35°C | Trypanosoma vivax | |
0.253 | - |
(2R,3R,4S,5S)-2-(hydroxymethyl)-5-phenylpyrrolidine-3,4-diol | - |
Trypanosoma vivax |