Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli WK6 cells | Trypanosoma vivax |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors, hanging drop vapour diffusion method, using 25% (w/v) PEG 3350 in 100 mM Bis-Tris buffer pH 6.5 and 0.2 M MgCl2 | Trypanosoma vivax |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol | nanomolar inhibitor | Trypanosoma vivax | |
(2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol | nanomolar inhibitor | Trypanosoma vivax | |
(2S,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol | nanomolar inhibitor | Trypanosoma vivax | |
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin H | - |
Trypanosoma vivax | |
immucillin H | immucilin H is (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol | Trypanosoma vivax |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma vivax | Q9GPQ4 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Superdex-200 gel filtration | Trypanosoma vivax |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine + H2O | - |
Trypanosoma vivax | D-ribose + adenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IAG-NH | - |
Trypanosoma vivax |
inosine-adenosine-guanosine-preferring nucleoside hydrolase | - |
Trypanosoma vivax |
purine-specific nucleoside hydrolase | - |
Trypanosoma vivax |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000041 | - |
(2S,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol | - |
Trypanosoma vivax | |
0.0000044 | - |
(2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol | - |
Trypanosoma vivax | |
0.0000062 | - |
immucillin H | - |
Trypanosoma vivax | |
0.0000108 | - |
(2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol | - |
Trypanosoma vivax |