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Literature summary for 3.2.2.1 extracted from

  • Sterk, M.; Mueller, J.; Hemphill, A.; Mueller, N.
    Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin (2007), Microbiology, 153, 4150-4158.
    View publication on PubMed
Search for more literature for 3.2.2.1

Inhibitors

Inhibitors Comment Organism Structure
daidzein enzyme is a major daidzein-binding protein Giardia intestinalis
formononetin
-
 Giardia intestinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
 Inosine pH 7.3, 37°C Giardia intestinalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, SDS-PAGE Giardia intestinalis

Organism

Organism UniProt Comment Textmining
Giardia intestinalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O best substrate Giardia intestinalis D-ribose + adenine
-
 ?
cytidine + H2O about 20% of the rate with adenosine Giardia intestinalis cytosine + D-ribose
-
 ?
guanosine + H2O about 80% of the rate with adenosine Giardia intestinalis D-ribose + guanine
-
 ?
inosine + H2O rate of hydrolysis similar to adenosine Giardia intestinalis hypoxanthine + D-ribose
-
 ?
uridine + H2O about 15% of the rate with adenosine Giardia intestinalis D-ribose + uracil
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Giardia intestinalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0038
-
 daidzein pH 7.3, 37°C Giardia intestinalis
0.011
-
 formononetin pH 7.3, 37°C Giardia intestinalis